OpioAlert for real time monitoring of opioid intoxication in far-forward deployed soldiers.

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911QY-19-P-0089
Agency Tracking Number: A183-142-0345
Amount: $99,771.56
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A18-142
Solicitation Number: 2018.3
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-03-29
Award End Date (Contract End Date): 2019-09-28
Small Business Information
5750 Shier Rings Rd, Dublin, OH, 43017
DUNS: 001004258
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Scott Angus
 (843) 573-0095
Business Contact
 Marcie Gagnon
Phone: (843) 573-0095
Email: marcie@guildbiosciences.com
Research Institution
Opioids are a class of potent analgesics used for both pain relief and their euphoric effects. The range of effective doses stretches across multiple orders of magnitude, down to micrograms per individual for a lethal dose. With such low doses causing significant intoxication, it is crucial to identify novel markers and means to monitor for opioid exposure both on the battlefield (opioid chemical threat) and in civilian settings (opioid epidemic crisis). Guild proposes to develop a wearable noninvasive opioid detector (OpioAert), capable of rapidly (<5 min) alerting of opioid intoxication at the point-of-need over a period of at least 10 days, without user intervention, by passively monitoring a soldiers blood for: 1) opioid and/or metabolites concentrationsclinical intoxication level; 2) respiratory depression with at least 4 clinical signs, prior to outward and observable clinical symptoms. OpioAert will improve outcomes based on trigger-to-treat or trigger-to-test by constant monitoring (24/7) and rapid alert of intoxication (<5 min) prior to outward clinical symptoms. OpioAert will be securely fitted to the soldiers body allowing for constant data collection during all battlefield operation. Battery life will be at least 10 days to allow monitoring during the 8-day deployment without requiring external power sources.

* Information listed above is at the time of submission. *

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