Rapid At-home Test for Monitoring Tacrolimus Levels in Plasma

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH19C0085
Agency Tracking Number: A183-145-0258
Amount: $149,882.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A18-145
Solicitation Number: 2018.3
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-05-20
Award End Date (Contract End Date): 2019-12-19
Small Business Information
2501 Earl Rudder Freeway South, College Station, TX, 77845
DUNS: 184758308
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Ritwik Ghosh
 (979) 764-2200
Business Contact
 Mrs. Taylor Blincoe
Phone: (979) 764-2200
Email: contract@lynntech.com
Research Institution
Vascularized composite allotransplantation (VCA) is a surgical approach for the clinical management of non-salvagable injuries. Tissue rejection is a major issue for patients receiving VCA. Tacrolimus is the most common immunosuppressant employed to minimize tissue rejections in VCA. The safety and efficacy of tacrolimus, which has a narrow therapeutic window is particularly sensitive to proper maintenance of drug plasma levels. With the currently available tacrolimus assays, plasma level monitoring can only be performed in a clinical laboratory setting. Development of a self-test would allow patients receiving VCA to monitor plasma tacrolimus levels at home, thereby reducing logistical burdens on both the health care system and the patients. Moreover, a home test will allow more frequent monitoring, thereby minimizing incidence of tissue rejections and adverse effects. Lynntech proposes to develop an innovative non-powered, portable microfluidic format that integrates sample preparation and assay performance within the same cartridge. A smartphone-based application allows data interpretation, storage and dissemination via wireless connectivity. Thus, Lynntechs platform represents an end-to-end solution that enables target biomolecule identification/quantification in a rapid (~20 minutes) and inexpensive (<$2) assay format. Operation of the assay requires minimal to no training and can be performed at home by patient or caregiver/family member.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government