Complex Crystalloid Resuscitative Fluid

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH19C0061
Agency Tracking Number: H2-0417
Amount: $1,000,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHA172-009
Solicitation Number: 2017.2
Timeline
Solicitation Year: 2017
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-05-13
Award End Date (Contract End Date): 2021-04-12
Small Business Information
119 Washington Ave, Miami Beach, FL, 33139
DUNS: 080737529
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Steed
 (412) 989-9819
 steeddl@hotmail.com
Business Contact
 George Sing
Phone: (917) 882-8001
Email: georgesing@gmail.com
Research Institution
N/A
Abstract
Problem: Currently available resuscitation fluids have been shown to induce detrimental effects on trauma outcomes.Objective: The objective of this proposal is to use the data from the successful Phase 1 studies to guide the continued development and testing of the novel resuscitation fluid (GND-001), which has been designed to address the deficiencies of current resuscitation fluids.Proposed work and expected results:The proposed work will involve refining the GND 001 formulation based on data from the Phase I proof-of-concept studies and in vitro testing using an endothelial cell model.The refinements to GND-001 will be tested for efficacy in a small animal hemorrhagic shock model compared to a) the original prototype as a benchmark, and b) the standard-of-care control.We will also examine the effects of the resuscitation fluid in a large animal hemorrhagic shock model.The swine model is well defined and the size of the animal allows for a longer study period, additional studies such as coagulation assays, and more frequent assay intervals that are not possible in the rodent model due to volume restrictions.Based on the phase I results, we expect the results to show improvements in acidosis and base deficit, and improvements in outcome.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government