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Chronological Sweat Sensor Patch for Real-Time Human Molecular Biomarker Monitoring

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH19C0073
Agency Tracking Number: H2-0449
Amount: $1,074,993.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHA18-003
Solicitation Number: 2018.1
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-06-03
Award End Date (Contract End Date): 2021-11-02
Small Business Information
12345 W. 52nd Ave., Wheat Ridge, CO, 80033
DUNS: 181947730
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Ambalavanan Jayaraman
 (303) 940-5391
 ajayaraman@tda.com
Business Contact
 Mr. John Wright
Phone: (303) 940-2300
Email: jdwright@tda.com
Research Institution
N/A
Abstract
Sweat contains biomarkers that give an indication of human cognitive levels. In this SBIR project TDA Research is developing a modular sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers, but also to collect multiple precisely time stamped chronological samples (50-150 Ls each) for off-line analysis in laboratory assays.In Phase I, we demonstrated the collection of multiple precisely time stamped chronological samples of artificial sweat for off-line analysis in a modular sensor patch. Using the same platform, we also demonstrated in breadboard systems the capability to measure sweat rate and biomarkers such as sodium. We also showed that the device itself does not alter the composition of the sweat and does not need any active pumping to move the sweat from the skin into the collection wells.In Phase II, we will further refine the design, fabricate multiple smart sweat patches and demonstrate repeatable and reproducible performance. The device will prevent cross-contamination of the chronologically collected sweat samples, measure sweat rate and include robust biomarker sensors that monitor one or more biomarkers in sweat. We will develop a strategy to secure FDA approval.

* Information listed above is at the time of submission. *

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