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Developing Software for Pharmacodynamics and Bioassay Studies

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-17-C-0153
Agency Tracking Number: H16C-001-0003
Amount: $149,935.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHP16C-001
Solicitation Number: 2016.0
Timeline
Solicitation Year: 2017
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-11
Award End Date (Contract End Date): 2018-04-10
Small Business Information
7926 Jones Branch Drive,
mclean, VA 22102
United States
DUNS: 001899546
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Hua Liang
 (202) 994-7844
 hlaing@gwu.edu
Business Contact
 Larry Liu
Phone: (703) 910-3400
Email: larry.liu@tconnex.com
Research Institution
 The George Washington University
 Tapan Nayak
 
2121 I Street, NW Array
Washington/, DC 20052
United States

 (202) 994-6549
 Nonprofit college or university
Abstract

Estimation of the primary parameters like IC 50 in traditional dose-response modelsmay fail or lead to misleading results when the observations are non-onotonic due to drugresistance or virus mutation in various biomedical lab research. The objective of this project isto develop a novel approach to assess dose response relationship, which is applicable to generalpharmacologic, toxicologic, or other biomedical studies that exhibit a non-monotonic dose-response relationship, and to develop inference tools. User-friendly software, that can handleboth monotonic and non-monotonic dose-response relationships, will be developed and availableto the scientific community.

* Information listed above is at the time of submission. *

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