STTR Phase II:Engineering Clostridial Fermentation for Biobutanol Production

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$500,000.00
Award Year:
2010
Program:
STTR
Phase:
Phase II
Contract:
1026648
Award Id:
88528
Agency Tracking Number:
0810568
Solicitation Year:
n/a
Solicitation Topic Code:
BE3
Solicitation Number:
n/a
Small Business Information
4734 Bridal Path Court, Dublin, OH, 43017
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
530001098
Principal Investigator:
I-ChingTang
(614) 761-1552
bictang@sbcglobal.net
Business Contact:
I-ChingTang
(614) 761-1552
bictang@sbcglobal.net
Research Institute:
Ohio State University Research Foundation -DO NOT USE
Shang-Tian Yang
1960 Kenny Rd
Columbus, OH, 43210
(614) 292-6611

Abstract
This STTR Phase II project will develop novel engineered Clostridia strains for fermentation and economically produce butanol as a biofuel from sugars derived from starchy and lignocellulosic biomass. The conventional acetone-butanol-ethanol (ABE) fermentation has low butanol yield (<25%), butanol concentration (<16 g/L), and reactor productivity (<0.5 g/L?h) due to a strong butanol inhibition, and the fermentation process is difficult to improve due to the complicated metabolic pathways and gene regulation involved in the production microorganisms, mainly Clostridium acetobutylicum. The broader impact/commercial potential of the project is to produce butanol as a biofuel from sugars derived from starchy and lignocellulosic biomass. Biobutanol has great value as an alternative transportation fuel. There is a huge potential commercial and societal impact in improving yields and reducing costs of butanol production. The research and other activity proposed could lead directly to a marketable product and process and leads to several enabling technologies, including better manipulation of C. tyrobutylicum, further demonstration of strain improvements using the FBB, and others.

* information listed above is at the time of submission.

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