STTR Phase II:Engineering Clostridial Fermentation for Biobutanol Production

Award Information
Agency:
National Science Foundation
Amount:
$500,000.00
Program:
STTR
Contract:
1026648
Solitcitation Year:
2010
Solicitation Number:
NSF 07-586
Branch:
N/A
Award Year:
2010
Phase:
Phase II
Agency Tracking Number:
0810568
Solicitation Topic Code:
EO
Small Business Information
Bioprocessing Innovative C
4734 Bridal Path Court, Dublin, OH, 43017
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
530001098
Principal Investigator
 I-Ching Tang
 (614) 761-1552
 bictang@sbcglobal.net
Business Contact
 I-Ching Tang
Phone: (614) 761-1552
Email: bictang@sbcglobal.net
Research Institution
 Ohio State University Research Foundation -DO NOT USE
 Shang-Tian Yang
 1960 Kenny Rd
Columbus, OH, 43210
 (614) 292-6611
 Nonprofit college or university
Abstract
This STTR Phase II project will develop novel engineered Clostridia strains for fermentation and economically produce butanol as a biofuel from sugars derived from starchy and lignocellulosic biomass. The conventional acetone-butanol-ethanol (ABE) fermentation has low butanol yield (<25%), butanol concentration (<16 g/L), and reactor productivity (<0.5 g/L?h) due to a strong butanol inhibition, and the fermentation process is difficult to improve due to the complicated metabolic pathways and gene regulation involved in the production microorganisms, mainly Clostridium acetobutylicum. The broader impact/commercial potential of the project is to produce butanol as a biofuel from sugars derived from starchy and lignocellulosic biomass. Biobutanol has great value as an alternative transportation fuel. There is a huge potential commercial and societal impact in improving yields and reducing costs of butanol production. The research and other activity proposed could lead directly to a marketable product and process and leads to several enabling technologies, including better manipulation of C. tyrobutylicum, further demonstration of strain improvements using the FBB, and others.

* information listed above is at the time of submission.

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