Developing Silicon Nanowire Sensors to Measuring Host-Cell Proteins at a Biomanufacturing Line

Award Information
Agency: Department of Commerce
Branch: National Institute of Standards and Technology
Contract: 70NANB19H075
Agency Tracking Number: 076-02-01 (PII)
Amount: $406,492.56
Phase: Phase II
Program: SBIR
Solicitation Topic Code: None
Solicitation Number: N/A
Timeline
Solicitation Year: 2019
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-01
Award End Date (Contract End Date): 2021-08-31
Small Business Information
173 Bedford Rd., Lincoln, MA, 01773
DUNS: 079689066
HUBZone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Marcie Black
 (954) 471-1357
 marcie@advancedsilicongroup.com
Business Contact
 Marcie Black
Phone: (954) 471-1357
Email: marcie@advancedsilicongroup.com
Research Institution
N/A
Abstract
Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be used as a cell line-specific platform for biomanufacturers who require custom sensors to measure host cell proteins for their specific cell lines. We will then make a portable system, including both the hardware and software, and bring it to a biomanufacturer’s line to do measurements side by side with ELISA tests. Lastly, we will teach their staff to run measurements using our sensors and system and use their feedback to write a manual for use.

* Information listed above is at the time of submission. *

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