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Multimode Chiroptical Spectrometer for Nanoparticle Characterization

Award Information
Agency: Department of Commerce
Branch: National Institute of Standards and Technology
Contract: 70NANB19H077
Agency Tracking Number: 005-02-07 (PII)
Amount: $406,475.59
Phase: Phase II
Program: SBIR
Solicitation Topic Code: None
Solicitation Number: N/A
Solicitation Year: 2019
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-01
Award End Date (Contract End Date): 2021-08-31
Small Business Information
3701 Kirby Drive, Ste 994
Houston, TX 77098
United States
DUNS: 184353774
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Tonya Cherukuri
 (713) 521-1450
Business Contact
 Tonya Cherukuri
Phone: (713) 521-1450
Research Institution

This project will develop a new scientific instrument optimized for the advanced characterization of near-infrared fluorescent nanoparticles that can exist as left- or right-handed structures (enantiomers). Single-walled carbon nanotubes (SWCNTs) are the leading current example of such nanomaterials. Applied NanoFluorescence, LLC (ANF) proposes a novel multi-mode chiroptical spectrometer that can distinguish left and right enantiomers through their different interactions with circularly polarized light. The planned instrument will offer four complementary measurement modes: (1) fluorescence-detected circular dichroism (FDCD) spectra with tunable visible excitation (400-700 nm) and near-infrared emission (900-1600 nm); (2) rapid excitation-emission fluorimetry covering the same visible excitation and near-infrared emission ranges; (3) direct near-infrared circular dichroism absorption spectra; and (4) normal near-infrared absorption spectra. Unlike existing FDCD instruments, mode (1) will offer spectral selection of the emission wavelength, thus allowing structure-specific measurements of CD spectra in unsorted SWCNT samples. Mode (2) will measure full excitation-emission maps with peak signal-to-noise ratios above 100 in less than 2 minutes. All four measurement modes will operate under integrated computer control. The combined results will offer powerful analyses of complex nanoparticle samples and their coatings, guiding research, product development, quality control, and commercial applications.

* Information listed above is at the time of submission. *

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