Fullerene Nanomedicine to Enhance Neuronal Adenosine Triphosphate Production Capacity

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-10-C-0010
Agency Tracking Number: A092-059-0905
Amount: $69,996.00
Phase: Phase I
Program: SBIR
Awards Year: 2009
Solicitation Year: 2009
Solicitation Topic Code: A09-059
Solicitation Number: 2009.2
Small Business Information
1 Riverside Circle, Suite 400, Roanoke, VA, 24016
DUNS: 627132913
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Zhiguo Zhou
 Principal Investigator
 (434) 483-4234
Business Contact
 Maggie Hudson
Title: Contracts Administrator
Phone: (434) 483-4254
Email: submissions307@lunainnovations.com
Research Institution
Cognitive performances are significantly reduced for older soldiers, due to the reduced production of the primary energy molecule of the body - adenosine triphosphate. The aging-dependent mitochondrial insufficiency is thought to play a dominating role. The development of a therapeutic drug which can enhance ATP production and improve energetic capability is crucial to maintain soldiers’ performance and extend their duty-time. The current attempts to counter mitochondrial insufficiency include frequent exercise and antioxidants, but the effects are very limited. Luna Innovations proposes to use nanomedicine technology to develop prototype compounds with stimulatory effects on neuronal ATP production. Luna has developed an extensive portfolio of fullerene nanosphere compounds which showed promises in treating aging-related diseases. Fullerene nanospheres are thought to scavenge the toxic free radicals generated in mitochondria, enhance the electron transport capacity in oxidative phosphorylation, and build a greater potential gradient across the inner membrane, efficiently driving ATP Synthase. In Phase I, Luna will develop and validate a high throughput screening assay based on the ATP-requiring luciferin-luciferase bioluminescence, and test nanosphere compounds to build a structure-activity relationship for designing and testing more compounds in Phase II.

* Information listed above is at the time of submission. *

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