Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$141,189.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43DK080567-01
Award Id:
85593
Agency Tracking Number:
DK080567
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
SCRA TRIDENT RESEARCH CENTER, 5300 INTERNATIONAL BLVD, NORTH CHARLSTON, SC, 29418
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
602545654
Principal Investigator:
GAUTAM GHATNEKAR
(843) 901-9989
GHATNEK@MUSC.EDU
Business Contact:
() -
ghatnek@musc.edu
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): According to the American Diabetes Association, there are more than 16 million people in the United States with known diabetes. Diabetic patients commonly demonstrate impaired wound healing. Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, require prolonged hospitalization, and may involve infection, gan grene, and amputation. It has been estimated that for each new foot ulcer the attributable cost for a middle-aged diabetic man in the first two years is approximately 30,000. The cost of DFU to the healthcare system is over one billion dollars per year i n the United States. A well- established reason as to why diabetic wounds are tough to heal is that they do not progress through the normal healing phases. Instead, it is thought that diabetic wounds are caught and remain trapped in the initial inflammator y phase of wound healing. FirstString Research, Inc. (FSR) is a biotech company located in Charleston, South Carolina. The founders of FSR, Drs. Robert Gourdie and Gautam Ghatnekar are co inventors of a class of novel bioengineered peptides - we refer to a s ACT peptides. Based on our data from treatment of acute wounds as well as preliminary data from wound healing in diabetic C57BL/KsJ-m+/+Leptdb (db+/db+) mice, we believe that our lead compound, ACT1 peptide will have beneficial effects in the treatment o f chronic wounds such as DFU's. ACT1 peptide has been shown to significantly dampen down the initial inflammatory response and promote faster and effective progression through wound healing. We hypothesize that ACT1 peptide will provide a unique, mechanist ically based approach to restoring normal progression of wound healing in diabetics. Milestones for Phase I project: 1. To determine whether or not ACT1 peptide promotes wound healing, and reduces inflammation in diabetic C57BL/KsJ-m+/+Leptdb (db+/db+) mic e. 2. To determine if topically applied ACT1 peptide on skin wounds in diabetic C57BL/KsJ-m+/+Leptdb (db+/db+) mice has any systemic effects as evaluated by blood analyses and necropsy. Present therapies and drugs for wound healing in diabetes and chron ic wounds in general are predominantly symptomatic, empirical, unpredictable, and largely ineffective The ACT1 peptide potentially offers a mechanistically based solution to not just faster wound closure but also significant cost savings and more important ly improving the quality of life in diabetic patients. The development of FSR's ACT1 peptide via milestones outlined in this SBIR, not only will meet this specific need for patients and surgeons, but also has the potential to lay a platform for broader cli nical applications and commercial opportunities.

* information listed above is at the time of submission.

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