NONLINEAR DYNAMICAL SEIZURE PREDICTION AND DETECTION

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS043100-01
Agency Tracking Number: NS043100
Amount: $97,668.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
FLINT HILLS SCIENTIFIC, LLC
FLINT HILLS SCIENTIFIC, LLC, 5020 W 15TH ST, STE A, LAWRENCE, KS, 66049
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MARY HARRISON
 (785) 838-3715
 MAFH@FHS.LAWRENCE.KS.US
Business Contact
 MARK FREI
Phone: (785) 838-3715
Email: FREI@FHS.LAWRENCE.KS.US
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Techniques from nonlinear dynamics are potentially valuable for prediction of epileptic seizures based on preliminary results with reported prediction times of up to several minutes before electrographic onset. These results must be validated using a database containing more subjects and longer time series with more than one seizure per series in order to establish their predictive sensitivity and specificity. Moreover, criteria for prospective inference must be developed at the same time as computational efficiency is improved, in order to be usable in real time. FHS, with proven expertise in epileptic signal analysis and a database containing over 2000 hours of ECoG recordings from 20 subjects with over 100 seizures, is ideally suited for this task. The end product of this proposed research will be a user-friendly software package for the detection, prediction, and quantification of epileptic seizures for use in a portable device or in diagnostic equipment. The introduction of this software will advance the field scientifically, clinically, and commercially. In Phase I, we will demonstrate proof of principle for this concept, assessing the value of the measures for the task of seizure prediction and detection, and quantifying their sensitivity to amplitude and frequency changes. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* information listed above is at the time of submission.

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