AMES+Brain Stimulation: Treatment for Profound Plegia in Stroke

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$233,630.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS067694-01A1
Award Id:
96459
Agency Tracking Number:
NS067694
Solicitation Year:
n/a
Solicitation Topic Code:
NINDS
Solicitation Number:
n/a
Small Business Information
AMES TECHNOLOGY, INC., 657 SW REGENCY PL, PORTLAND, OR, 97220
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
180254620
Principal Investigator:
PAUL CORDO
(503) 970-6129
CORDOP@AMESDEVICES.COM
Business Contact:
PAUL CORDO
() -
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): An estimated 30% of chronic stroke patients with motor disabilities of the limbs are plegic in the hand or the foot - that is, they cannot move the hand or foot. While some plegic stroke patients have completely paralyz ed muscles, without the ability to activate even minimally the plegic muscles ( profound plegia ), other plegic stroke patients are capable of producing volitional muscle activation, but are not strong enough to make the joint move ( pseudo plegia ). The l ong-term objective of this study is to restore functional movement to stroke patients with profoundly plegic muscles and with pseudo plegic muscles. Stroke is the leading cause of disability in the U.S., amounting to 50 billion in health care costs annual ly. Each year, about 700,000 US citizens suffer stroke, and those who survive without full recovery join a growing population of chronically disabled individuals currently totaling 5.8 million. Any therapeutic intervention that effectively treats plegic st roke patients will have significant impact on the productivity, quality of life, and healthcare expenses of stroke patients in the U.S. and worldwide. The work proposed in this application addresses the treatment of low functioning plegic stroke patients t hrough the use of a recently developed therapeutic intervention called AMES (Assisted Movement with Enhanced Sensation). AMES therapy involves a robotic device that moves the paretic or plegic joint while the patient assists the motion and observes visua l biofeedback - in the form of joint torque for paretic individuals, or muscle activity (EMG) for plegic individuals - about their level of assistance. While the robotic device moves the joint, vibrators on the AMES therapy device stimulate sensory recepto rs in the lengthening muscles to enhance the sensation of joint motion and displacement. AMES treatment has already been shown to be an effective treatment for most low-functioning stroke patients with paresis, helping them regain functional movement. In A im 1, we will redesign the robotic grasp mechanism of the AMES device to increase its sensitivity so that it will be able to measure low levels of torque during AMES hand therapy - at levels beyond the capacity of the current AMES device. This increased se nsitivity will allow us to detect with precision the point at which AMES therapy causes a patient to transition from plegia to paresis. In Aim 2, using AMES therapy combined with brain stimulation (rTMS or tDCS), our goal is to restore volitional EMG to pr ofoundly plegic muscles and, thereby, convert these muscles into pseudo plegic muscles. PUBLIC HEALTH RELEVANCE: The proposed research addresses the sensorimotor rehabilitation of low-functioning stroke patients with hand plegia, a sub-population no t served by currently available therapeutic approaches. The objective is to use AMES therapy in combination with brain stimulation to restore volitional muscle activity in this population. AMES+brain stimulation is envisioned to be the first of 3 forms o f AMES therapy in a progressive therapeutic regimen for profoundly plegic stroke patients that would, first, restore volitional muscle activity (EMG) via AMES+brain stimulation, next, restore some minimal movement via AMES+EMG biofeedback, and lastly, rest ore functional movement via AMES+torque biofeedback.

* information listed above is at the time of submission.

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