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CNT-Vectored Delivery of mRNA for HIV-Vaccines

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N93019C00034
Agency Tracking Number: N44AI190034
Amount: $1,999,997.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
301 1ST STREET SW, SUITE 200
ROANOKE, VA 24011-1921
United States
DUNS: 627132913
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Yang Xu
 (434) 483-4254
 xuy@lunainc.com
Business Contact
 Yang Xu
Phone: (434) 483-4254
Email: xuy@lunainc.com
Research Institution
N/A
Abstract

Developing safe and effective preventives for HIV remains the hope for controlling the global AIDS epidemicRecentlymRNA vaccines have emerged as a promising alternative to conventional vaccine approaches because of their high potencycapacity for rapid developmentpotential for low cost manufactureTo datethere is no effective mRNA protective vaccine for HIVand the need for one is vastDespite the advantages of mRNA vaccineschallenges remainincluding how to protect mRNA from degradationincrease the short in vivo half lifeand ensure uptake by cells and efficient expression in the cytoplasmAs a resultthere is a necessity to formulate mRNA vaccines with novel and effective delivery systems to overcome these obstacles and provide functional vaccinationLuna is developing a novel and effective carbon nanotube based mRNA delivery platform for HIV vaccineThis is the first reported mRNA encoding HIVglycoprotein as a novel mRNA vaccine candidateMost importantlyLuna s CNTVac mRNA candidates have demonstrated generation of potent and specific HIV neutralizing antibody IgG and IgA titers in mice after subcutaneous injectionLuna is working on the preclincal studies including immunogenicityefficacy and safety studies in the Phase II program in preparation for filing an IND to prevent HIV infections

* Information listed above is at the time of submission. *

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