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Advanced development of a novel nanoparticle conjugate vaccine for Salmonella Paratyphi A

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N93019C00029
Agency Tracking Number: N44AI190029
Amount: $2,972,412.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: N/A
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2151 Harvey Mitchell Parkway, Suite 306, COLLEGE STATION, TX, 77840-5237
DUNS: 832760131
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Yawei Ni
 (979) 217-6831
Business Contact
 Yawei Ni
Phone: (979) 217-6831
Research Institution
Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein carrier found exclusively in bacteria and archaeaBasic processes for generation of purified polysaccharide antigen and carrier protein and their chemical conjugation were successfully establishedThe resulting conjugates were shown to be highly immunogenic in animal studiesWe propose to continue development of this novel conjugate vaccine in this phase II proposal with activities including advanced immunogenicity evaluationpilot cGMP process and assay developmentstability studyand animal toxicology study which will form the basis for the clinical stage developmentSuccessful development and licensure of this vaccine in the US will meet a significant unmet need for protection of high risk US populations in light of the increasing prevalence of SParatyphi A in other parts of world and ever increasing international travelsIt could also lead to a new and more effective nanoparticle based approach for conjugate vaccines

* Information listed above is at the time of submission. *

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