METHOD FOR EVALUATION OF DRUG RESISTANCE FOR PLASMODIUM FALCIPARUM

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 15843
Amount: $536,543.00
Phase: Phase II
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
6127 Sw Corbett, Portland, OR, 97201
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr Michael T Makler
 Principal Investigator
 (503) 721-7820
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE DETECTION OF DRUG RESISTANT FORMS OF PLASMODIUM FALCIPARUM HAS TRADITIONALLY REQUIRED A 24-48 HR CULTURE PERIOD WITH ANALYSIS CONDUCTED BY MICROSCOPICALLY MEASURING THE LEVEL OF PARASITEMIA FOR EACH TEST POINT. IT IS OUR INTENT TO MODIFY THIS PROCEDURE TO ALLOW EARLIER DETECTION OF THE DRUG RESISTANT FORM OF THE PARASITE AND TO PERMIT THIS DETECTION TO BE MADE WITH SIGNIFICANT REDUCTION IN MAN-POWER REQUIREMENTS. THE ASSAY IS BASED ON DETECTION OF METABOLIC METABOLIC PRODUCTS OF THE PARASITE DURING ITS GROWTH PHASE. THESE METABOLIC PRODUCTS WILL BE MEASURED BY STANDARD TECHNIQUE. THUS THE ASSAY FOR DRUG RESISTANCE WILL BE DEPENDENT ON AN ALTERATION OF THE METABOLISM OF THE PARASITE RATHER THAN DIRECT MEASUREMENT OF PARASITE MULTIPLICATION.

* Information listed above is at the time of submission. *

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