ACUTE THROMBOSES OF ARTERIES ARE USUALLY A MEDICAL EMERGENCY.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$46,211.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3238
Agency Tracking Number:
3238
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
21414 68th Avenue S., Kent, WA, 98032
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
G. STUART KNOKE
PRINCIPAL INVESTIGATOR
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
ACUTE THROMBOSES OF ARTERIES ARE USUALLY A MEDICAL EMERGENCY. THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PULSED FLUIDJET SYSTEM FOR INTRAVASCULAR USE TO HYDRAULICALLY REMOVE CLOTS AND DEBRIS FROM OCCLUDED ARTERIES VIA SMALL CALIBER ANGIOGRAPHIC CATHETERS. WE PROPOSE A PULSED FLUID IRRIGATION SYSTEM COMBINED WITH ASPIRATION THROUGH THE LUMEN OF THE CATHETER. A SPECIALIZED PUMP, CATHETER, AND CONTROL SYSTEM WILL BE DEVELOPED. THE PUMP WILL PROVIDE VARIABLE PRESSURE, FLOW, AND PULSE PATTERN. THE ATTENUATION OF THE PRESSURE PULSE IN THE CATHETER WILL BE ANALYZED TO OPTIMIZE THE JET. THE CONTROLS WILL ALLOW THE PHYSICIAN TO SELECT VARIOUS OPERATING PARAMETERS FOR THE CUTTING JET. THE GOAL OF PHASE I IS ESTABLISH THE FEASIBILITY OF SUCH A SYSTEM THROUGH LABORATORY TESTING OF CATHETERS AND DETERMINATION OF CUTTING PARAMETERS ON TISSUE SAMPLES. DURING PHASE II, THE SYSTEM WILL BE FABRICATED AND REFINED THROUGH IN VITRO AND IN VIVO ANIMAL TESTING. THE RESULTING SYSTEM FOR CLEARING THROMBI WILL HAVE IMMEDIATE COMMERCIAL APPLICATION AND COULD IMPROVE THE HEALTH CARE OF MILLIONS OF PATIENTS.

* information listed above is at the time of submission.

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