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Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R44MH115955-01
Agency Tracking Number: R44MH115955
Amount: $732,288.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 101
Solicitation Number: PAR14-265
Solicitation Year: 2014
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-01-23
Award End Date (Contract End Date): 2021-12-31
Small Business Information
1776 MILLRACE DR STE 301, Eugene, OR, 97403-2536
DUNS: 081010564
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (541) 653-8266
Business Contact
Phone: (541) 687-7962
Research Institution
This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technology will be fully commercialized as a medical device through addressing four specific aims guided by the goals for noninvasive neuromodulation in the BRAIN InitiativeWe will improve focal current delivery at deep as well as superficial brain locations with a novel targeting algorithmDiscriminative Cortical Source Vectoringimplemented with a high resolution conductivity model of the human headBoth simulation and experiment will be used to minimize extraneous stimulation to non target regions while quantifying current delivered to all brain regionsWe will design and test a placebo mode to allow definitive clinical trialsClosed loop operation will be achieved by guiding the localization and phase of GTEN intervention with simultaneous monitoring of source localized EEGIn the validation of closed loop operationthe EEG rhythms will be those of slow wave sleepand they will be hypothesized to be enhanced in both depth and length during the nightandapos s sleepCompleting the aims of this SBIR will create a dEEG guided noninvasive dense array electrical neuromodulation technology as a powerfulpreciseand inexpensive technology for both research and clinical practice The abnormal brain activity in mental disorders is often reflected in patterns of the electrical fields of the brainIn additionseveral studies suggest that it is possible to apply weak electrical fields safely to the brain in order to change its ongoing activityThe proposed research project would address a number of challenges that must be faced in order to improve the delivery of electrical treatments to the brain that are aligned precisely in space and time to optimize the influence on ongoing brain activity

* Information listed above is at the time of submission. *

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