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Bioinformatic Tools for Interpretation of Glycan Array Data

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM131430-01
Agency Tracking Number: R43GM131430
Amount: $571,833.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 400
Solicitation Number: PA18-574
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-01-01
Award End Date (Contract End Date): 2020-12-31
Small Business Information
12635 E. Montview Blvd., Suite 214
Aurora, CO 80045-7337
United States
DUNS: 079149797
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (720) 859-3551
Business Contact
Phone: (720) 859-3551
Research Institution

Project SummaryAbstract There is an urgent need of bioinformatic tools for mining glycan array data in order to accurately and statistically study the interactions between cell surface glycans and glycan binding proteinsWe propose here to develop a software and hardware integrated system for the interpretation of glycan array dataThe problem with existing glycan array data mining tools is that they give binding information only for simplistic substructures of glycans and not complex binding determinantsand also that they are not automatedTo solve this problemZ BiotechLLCa glycan array providerwill team with DrBrian Haab s lab in Van Andel Research Institutea software providerto develop and improve a robust glycan array data mining toolMotifFinderZ Biotech has invented a robust glycan array platform having the advantage to display glycans on solid surfaces in a multivalent formThe glycan arrays Z Biotech provides have superior performance with the criteria for a high quality microarraywhich is suitable for generation of glycan array data for evaluation of a bioinformatic tool like MotifFinderIn additionThe Haab research group has been leading developments in glycan array bioinformaticsThey were the first to publish an algorithm for the analysis of glycan array data inand subsequently have contributed many innovationsThe proposed research strategy has been supported by a preliminary experimental investigation under collaboration between the two glycoscience groupsIn Phase Ithe specific aims aredevelopment of a catch allGlycan Array as a primary array for software testingmanufacture individual glycan array subarrays and run assays used for testing softwareandoptimize and validate software for the automated interpretation of glycan array dataThese are realistic goals within the SBIR program scopeand the resultant glycan array packages with hardware and software will have a broad impact on glycobiology researchglycan related biomarker characterizationand new drug development targeting glycans Project Narrative Glycan array is a vital tool for studying carbohydrate protein interactionsbiomarker discoveryand potentially drug screening and there is need for a bioinformatics tool for interpretation of glycan array dataThe goal of this SBIR project is to develop a robust bioinformatics tool for the analysis of glycan array dataThe resulting bioinformatic tools will also deepen our understanding of how glycans contribute to diseasessuch as cancers and infectious diseases

* Information listed above is at the time of submission. *

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