Novel sanitizer/disinfectants against viral infections with long-lasting effect

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R42AI124738-02
Agency Tracking Number: R42AI124738
Amount: $705,771.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA18-575
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2018-12-01
Award End Date (Contract End Date): 2020-11-30
Small Business Information
1120 15TH ST CA 2151, Augusta, GA, 30912-0004
DUNS: 968429386
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 STEPHEN HSU
 (706) 721-4816
 shsu@augusta.edu
Business Contact
 STEPHEN HSU
Phone: (706) 721-4816
Email: shsu@augusta.edu
Research Institution
 AUGUSTA UNIVERSITY
 1120 15TH STREET
AUGUSTA, GA, 30912-0004
 Nonprofit college or university
Abstract
AbstractNorovirus is the most common cause of acute gastroenteritis in the United Statesassociated annually withmillion illnesseshospitalizations anddeathsUS CDCOverview about NorovirusNorovirus is one of the nonenveloped viruses that are resistant to alcohol sanitizationAccording to US CDC Guidelines for the Prevention and Control of Norovirus Gastroenteritis Outbreaks in Healthcare Settingsthe primary method for prevention of norovirus transmission by hand is hand wash with soap and waterHoweverthis method does not inactivate norovirusbut rather releases and washes the virus off the skinCurrently available agents that are able to inactivate norovirus are toxic to human cellsIn factviral outbreaks worldwide are on the rise despite the increased effort to prevent themOur goal is to develop several effectivenon toxicenvironment friendly hand sanitizer surface disinfectants to aid in the prevention of viral outbreaksparticularly norovirus preventionDuring Phase I of the STTR projectwe focused on testing the proof of concept that novel sanitizer formulationsProtecTeaVcontaining EGCG palmitate are capable of inactivating norovirus and bacteriaWe have successfully identified ProtecTeaV formulations with virucidal activity and this activity persists on a clean surface beyond ahour periodThe new findings have been published in the International Journal of Microbiology andampInfectious DiseasesWidjaja et alThe objectives of our Phase II proposal include optimization and finalization of the ProtecTeaV formulation in several prototypestesting these prototypes and receiving approval from regulatory agenciesand conversion of the prototypes to large scale production ready productsThe Randamp D effort will continue to be based on the existing strong partnership between Camellix and Augusta Universityour current manufacturer partnerand experts in formulationregulatoryproductionand business developmentWe expect to launch the first ProtecTeaV product at the completion of this project Project Narrative Currently used alcohol based hand sanitizers are ineffective against nonenveloped viruses such as norovirusthe most common cause of gastroenteritisand the effectiveness of alcohol only lasts for less thansecondsBased on patented technologywe have identified an effectivenon toxicenvironment friendlyand long lasting sanitizer formulation against norovirusIn the Phase II proposalwe will optimize and finalize the formulation to produce several prototypes for regulatory approval and prepare to scale up for mass production

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government