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Vascular Deformation Mapping (VDM) for Automated, 3D Assessment of Thoracic Aortic Aneurysm

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R44HL145953-01
Agency Tracking Number: R44HL145953
Amount: $166,890.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NHLBI
Solicitation Number: PA18-574
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-05-01
Award End Date (Contract End Date): 2020-02-29
Small Business Information
227 COLFAX AVE N
Minneapolis, MN 55405-1402
United States
DUNS: 078397649
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CHARLES HATT
 (734) 915-7992
 charleshatt@imbio.com
Business Contact
 STEVE KOHLMYER
Phone: (262) 880-5099
Email: stevekohlmyer@imbio.com
Research Institution
N/A
Abstract

PROJECT SUMMARY Thoracic aortic aneurysmTAAis a chronic condition that carries the risk of developing life threatening complications such as aortic dissectioni edelamination of the aortic walland rupturei etransmural tearingThe primary management objectives for TAA are to identify aortic dilation early and to surgically replace the aorta before it reaches a size that predicts future complicationsIt is estimated thatmillion patients in the US alone would meet criteria for aortic imaging surveillance based on current guidelinesImproved imaging surveillance strategies are needed to address the health and economic impacts of TAAHoweverthe reliability of standard aortic diameter measurements from CT images remains lowIn this proposalwe will utilize a recently developed image analysis techniqueVascular Deformation MappingVDMto perform semi automatedthree dimensional assessment of aortic growth in patients with TAA undergoing imaging surveillanceThis novel approach utilizes advanced computerized analysis techniques that make full use of the richhigh resolutionvolumetric data generated by modern CT scannersto generate a more comprehensive and reliable assessment of aortic growthVDM has the ability to significantly improve the speed and reliability of TAA growth analysisfacilitate the communication of aortic growth assessment between radiologistscare providers and patientsand generate new biomarkers of disease progression that can be used to improve patient management decisionsand ultimately patient outcomesIn this grant effortwe propose to achieve the goals of this project through our close partnership between University of MichiganUMand ImbioLLC investigatorsThus the Specific Aims of this Fast Track proposal will develop a commercial VDM software applicationincluding the product testing and data acquisition necessary for a FDAkapplication NARRATIVEThoracic aortic aneurysmTAAis a chronic condition that carries the risk of developing lifethreatening complicationsIt is estimated thatmillion patients in the US alone would meet criteria for aortic imaging surveillance based on current guidelinesStandard methods of monitoring aortic growth are unreliableVascular Deformation MappingVDMis a new technology that can reliably track and display aortic growth inDThis project will implement VDM as clinical grade software and validate the technique in a large cohort of patients in preparation of an application for FDA approval!

* Information listed above is at the time of submission. *

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