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BEST-OUD: Behavioral Economic Screening Tool of Opioid Use Disorder for use in clinical practice

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DA048689-01
Agency Tracking Number: R41DA048689
Amount: $213,783.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 41
Solicitation Number: PA18-575
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-30
Award End Date (Contract End Date): 2020-08-31
Small Business Information
709 S JEFFERSON
Roanoke, VA 24016-5103
United States
DUNS: 080751297
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SARAH SNIDER
 (862) 268-3971
 sniders87@gmail.com
Business Contact
 SARAH SNIDER
Phone: (862) 268-3971
Email: sniders87@gmail.com
Research Institution
 VIRGINIA POLYTECHNIC INST AND ST UNIV
 
300 TURNER STREET NW SUITE 4200
BLACKSBURG, VA 24061-6100
United States

 Nonprofit college or university
Abstract

PROJECT SUMMARY Fatal overdose from opioid misuse is one of the most pressing issues affecting the modern worldAs one of the nation s leading preventable causes of deatha critical line of defense against opioid use disorderOUDmust be standardized screening provided by the patient s primary care physicianpsychiatristand or counselorStandardized screening methods for opioidshoweverare simply inferior and no gold standards existReform proposals call for improved technology for electronic screening to save time and improve standards of careMoreoverthe National Institute of Mental Health s Research Domain CriteriaRDoCframework prescribes a focus on defining the underlying functional dynamics of OUD instead of using symptom based tools as biomarkers for diseaseThereforethe present proposal aims to develop a validatedtheoretically guided toolwhich provides clinicians with information beyond OUD symptomsReinforcer pathology is a measure of severity derived from the synergy between two distinct decision making processespreference for immediately available small rewardsi eexcessive delay discountingandover valuation of substances such as opioid prescription pillsi ehigh behavioral economic demandParamount to this proposaldecades of research have concluded that delay discounting and demand are highly correlated with substance use severity and important predictors of OUD treatment successIn order to develop a feasible and acceptable reinforcer pathology based mobile tablet applicationBEST OUDfor use in the clinicthe present proposal aims to recruit clinicians to provide feedback via semi structured interview sessionsAimand integrate the BEST OUD application into their practiceAimaDevelopmentiterationand maintenance of the appincluding the user interface and back endsecure databasescore calculationand associated web portal will be built and maintained by BEAM DiagnosticsIncAimA total of three tool prototype iterationsbased on clinician feedbackwill be administered to clinic patients throughout the testing period to collect reinforcer pathology scores and patient feedbackAimbThis reinforcement pathology assessment tool is innovative given its propensity to bypass self report of past substance use behavior and OUD symptomsand prospectively predict severity based on a theoretical frameworkmaking this Phase I STTR application both timely and necessary PROJECT NARRATIVE Currentlyovermillion Americans suffer from opioid use disorderOUDa disease characterized by significant impairment or distressand many of these individuals will ultimately transition to strongerillegaland dangerous opioids such as heroinyet the current standardized screening measures for opioid misuse in clinical practice are poor and test only symptoms of past behaviorInsteadand in response to National Institute of Health s call for increased translation of theoretically based screening tools that examine core functions of substance use disordersthe reinforcer pathology framework examines an individual s decisionmaking processes about opioid use providing the clinician with more information about patient OUD severity and prospective riskThe current proposal seeks to develop and test the feasibility of a reinforcer pathology mobile tablet application to rapidly assess OUD severity and risk in the clinicproviding improved screening of vulnerable patients

* Information listed above is at the time of submission. *

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