HIGH-RESOLUTION ION BEAM PROBE FOR BIOLOGICAL RESEARCH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,560.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43EB000387-01
Agency Tracking Number:
EB000387
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
FM TECHNOLOGIES, INC.
FM TECHNOLOGIES, INC., 10529-B BRADDOCK RD, FAIRFAX, VA, 22032
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
SAMAR GUHARAY
(703) 941-0490
SGUHARAY@FM-TECHNOLOGIES.COM
Business Contact:
F MAKO
(703) 425-5111
FMAKO@EROLS.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Mapping the distribution of targeted chemical species in tissues is important in many areas of biology and medicine. These measurements require a highly sensitive methodology giving an accurate measure of the minute quantities of material in cells as well as the spatial resolution distinguishing organelles. Secondary Ion Mass Spectroscopy (SIMS) has intrinsic merits to serve this purpose. Much higher resolution, than the currently available value of 0.5 micrometer, is desired to make a strong headway with SIMS for ultra-fine imaging at cellular and sub-cellular level. The primary demand to achieve this goal is a high-brightness ion beam probe at low energy, using either oxygen or cesium species.The proposed work aims at developing a novel, high-brightness ion-optical column for SIMS and achieving a target spot size of about 10-20 nanometer and a current density of -1 ampere per square centimeter for oxygen ions.Success of this work will cross the present technological barrier for addressing several fundamental problems in cell biology relevant to the studies of carcinogenesis, toxicology, neurochemistry and the diagnosis of several diseases including cancer. Additionally, this project will immediately benefit many other areas in biology and medicine and nanotechnology overall.

* information listed above is at the time of submission.

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