You are here

Universal Membrane Dehydrator for Dewatering Pharmaceutical Solvents

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM135149-01
Agency Tracking Number: R43GM135149
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 400
Solicitation Number: PA18-574
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-01
Award End Date (Contract End Date): 2020-06-30
Small Business Information
335 WATER ST
Wilmington, DE 19804-2410
United States
DUNS: 808898894
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 KENNETH PENNISI
 (302) 999-7996
 kpennisi@compactmembrane.com
Business Contact
 RYAN COOK
Phone: (302) 999-7996
Email: rcook@compactmembrane.com
Research Institution
N/A
Abstract

Project Summary Specific AimThere are numerous needs in the pharmaceutical industry to use and recover high purity solventsKey uses includehigh purity alcohol for various applicationsthe ability to develop low cost dewatering of solvents and a relatively gentle and simple process for dewatering solvent under mild conditionsCompact Membrane SystemsCMSproposes a novel membrane process that can lead to extremely high dewatering rates with high separation capabilities based on a totally perfluoropolymerPFPmembrane system operating under a wide rangealmost universalof operating conditionsCMS s dewatering process is compatible with existing pharmaceutical solventPSprocessingThereforefrom a chemical stability standpointit can be operated with alcoholsorganic acidsketonesamines and aprotic solventsto name a fewTo enhance the potential foruniversalPS dehydrationCMS will totally remove the porous support and also use PFP pottingProduct ConceptTo develop a universal membrane dehydratorUMDthe whole system needs to be PFP basedRight nowwhile the CMS membrane is PFP basedthe membrane sits on a hydrocarbon porous support and uses a hydrocarbonHCepoxy potting systemUsing proprietary processing technology in combination with our expertise in the synthesis and know how in PFPwe will fabricate UMD that eliminate hydrocarbon based components from the final productThis will be done byminimizing hydrocarbon based componentsandremoving hydrocarbon based components that are used in processingRecent EventsEPA has established new safeguards for hazardous secondary materials recyclingThe objectives of these new safeguards are to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical manufacturer use at leastkg of solvents to makekg of active pharmaceutical ingredientEPA has determined that the environmental impacts from solvents used as manufacturing and processing aids could be significantly reduced if the product life of solvents used for these purposes were extended to more than a single useSee letter of support from EPAExisting Separation TechnologiesThe commercial standard dehydration procedure is molecular sieve dryingPolyvinyl alcoholPVAmembranes have historically been the standard membrane dehydratorOur results show the CMS membranes are simplerbetter and dramatically more stable than PVA membranesProgram ObjectivesMilestonesThe key program objectivemilestone will be achieving areduction in contaminants being in the extracted solutions Narrative There are numerous needs in the pharmaceutical industry to use and recover high purity solventsincluding dehydrating solvents by a universal dehydration process under conditions less severe than boilingA universal membrane dehydratorUMDwould need to be totally perfluoropolymers based to prevent hydrocarbon contaminationUsing our unique processing technology in combination with our expertise in the synthesis and know how in perfluoropolymerswe will develop an UMD that eliminate hydrocarbon based components from the final product

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government