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Targets of Acquired Tick-Resistance As Anti-Tick Vaccines

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI145778-01A1
Agency Tracking Number: R41AI145778
Amount: $299,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA18-575
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-07-01
Award End Date (Contract End Date): 2021-06-30
Small Business Information
300 GEORGE ST STE 309, New Haven, CT, 06511-6662
DUNS: 142406110
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 SUKANYA NARASIMHAN
 (203) 737-2642
 sukanya.narasimhan@yale.edu
Business Contact
 MARTIN MATTESSICH
Phone: (203) 494-5288
Email: mmattessich@l2dx.com
Research Institution
 YALE UNIVERSITY
 OFFICE OF SPONSORED PROJECTS, PO BOX 208327
NEW HAVEN, CT, 06520-8327
 Nonprofit college or university
Abstract
ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by the blacklegged tickIxodes scapularisby targeting tick salivary proteinsSalpscritical for tick feedingIscapularis Salps provide functions critical for evading host defense responses detrimental to the tickFurtherthese salivary functions are also co opted by tick transmitted pathogens to ensure their survival in the hostWe reason that tick Salps critical for tick feeding might serve as vaccine targets to impair tick feeding and consequentlyalso thwart the transmission of multiple tick borne pathogensOur hypothesis is validated by the phenomenon of acquired tick resistance whereinupon repeated tick infestations non permissive hosts such as rabbitsand guinea pigs mount a robust immune response against tick Salps critical for tick feeding and this results in rapid rejection of ticksTick resistance has also been shown to prevent transmission of BburgdorferiExploiting this phenomenonwe have identified several Salps that are avidly recognized by tick resistant animal seraSince tick resistant sera recognize multiple Salps it is reasonable to expect that multiple immunodominant Salps might have to be targeted simultaneously to recapitulate tick resistance and achieve robust tick rejectionIn this research studywe willAssess the vaccine potential of a combination of immunodominant Salps to prevent tick feeding in conjunction with adjuvants approved for human useExamine the utility of simultaneously targeting multiple immunodominant tick Salps to prevent the transmission of two tick transmitted pathogensBburgdorferi and AphagocytophilumThis combination strategy targeting multiple Salps simultaneously has the potential to result in a vaccine that might block the transmission of multiple Iscapularisborne pathogens NARRATIVE This Phase I proposal will develop a novel anti Iscapularis vaccine by targeting immunodominant tick salivary protein antigens to prevent tick feeding and consequently impair the transmission of multiple Iscapularis transmitted pathogens

* Information listed above is at the time of submission. *

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