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Targets of Acquired Tick-Resistance As Anti-Tick Vaccines

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI145778-01A1
Agency Tracking Number: R41AI145778
Amount: $596,625.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA18-575
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-07-01
Award End Date (Contract End Date): 2021-06-30
Small Business Information
300 GEORGE ST STE 309
New Haven, CT 06511-6662
United States
DUNS: 142406110
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SUKANYA NARASIMHAN
 (203) 737-2642
 sukanya.narasimhan@yale.edu
Business Contact
 MARTIN MATTESSICH
Phone: (203) 393-9439
Email: mmattessich@l2dx.com
Research Institution
 YALE UNIVERSITY
 
OFFICE OF SPONSORED PROJECTS, PO BOX 208327
NEW HAVEN, CT 06520-8327
United States

 Nonprofit college or university
Abstract

ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by
the blacklegged tick, Ixodes scapularis, by targeting tick salivary proteins (Salps) critical
for tick feeding. I. scapularis Salps provide functions critical for evading host defense
responses detrimental to the tick. Further, these salivary functions are also co-opted by
tick-transmitted pathogens to ensure their survival in the host. We reason that tick Salps
critical for tick feeding might serve as vaccine targets to impair tick feeding and
consequently, also thwart the transmission of multiple tick-borne pathogens.Our hypothesis is validated by the phenomenon of acquired tick-resistance
wherein, upon repeated tick infestations non-permissive hosts such as rabbits, and
guinea pigs mount a robust immune response against tick Salps critical for tick feeding
and this results in rapid rejection of ticks. Tick-resistance has also been shown to
prevent transmission of B. burgdorferi. Exploiting this phenomenon, we have identified
several Salps that are avidly recognized by tick-resistant animal sera.Since tick-resistant sera recognize multiple Salps it is reasonable to expect that
multiple immunodominant Salps might have to be targeted simultaneously to recapitulate
tick-resistance and achieve robust tick rejection. In this research study, we will:1. Assess the vaccine potential of a combination of immunodominant Salps to
prevent tick feeding in conjunction with adjuvants approved for human use.2. Examine the utility of simultaneously targeting multiple immunodominant tick
Salps to prevent the transmission of two tick-transmitted pathogens, B. burgdorferi and
A. phagocytophilum.This combination strategy targeting multiple Salps simultaneously has the
potential to result in a vaccine that might block the transmission of multiple I. scapularis-
borne pathogens.NARRATIVE
This Phase I proposal will develop a novel anti-I. scapularis vaccine by targeting
immunodominant tick salivary protein antigens to prevent tick feeding and consequently
impair the transmission of multiple I. scapularis-transmitted pathogens.

* Information listed above is at the time of submission. *

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