Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41NS113694-01
Agency Tracking Number: R41NS113694
Amount: $376,286.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 999
Solicitation Number: PA18-575
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-30
Award End Date (Contract End Date): 2020-08-31
Small Business Information
1828 FLOWER DR, Palm Beach Gardens, FL, 33410-1700
DUNS: 016937723
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 CORINNE LASMEZAS
 (561) 228-3456
 lasmezas@scripps.edu
Business Contact
 DENIS SHULYAEV
Phone: (561) 444-3951
Email: vovaida@aol.com
Research Institution
 SCRIPPS FLORIDA
 130 SCRIPPS WAY
JUPITER, FL, 33458-5284
 Domestic nonprofit research organization
Abstract
SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and aggregation of a host proteinWhile many of the steps leading to neurodegeneration in PD are still unknownsynucleinsynappears to be central to the pathological processLewy Bodiesthe neuropathological hallmark of PDare constituted mainly of phosphorylatedaggregatedsynThere is currently no disease modifying treatment for PD or othersynucleinopathies and there is an urgent need for new treatment optionsThe goal of the present phase I STTR application is to develop and validate a high throughput screeningHTSready assay for the large scale unbiased identification of compounds reducing the levels of a recently identifiedhighly neurotoxicform ofsyncalled psynCompletion of the proposed work plan will enable an HTS campaign and open up the way to develop new neuroprotective compoundsthereby addressing a critical barrier to progress in the field of therapeutic intervention for PD and other synucleinopathies!!Parkinsonandapos s disease is a neurodegenerative disease affecting over a million people in the United Statesfor which there are only symptomatic treatmentsA host proteincalledsynucleinforms neurotoxic aggregates in the brains of affected patientsThis phase I project will enable the discovery of chemical compounds reducing the amounts of toxicsynucleinopening up the way to develop disease modifying drugs

* Information listed above is at the time of submission. *

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