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Product Development of Intensity Modulation for Bolus Electron Conformal Therapy

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44CA199838-02
Agency Tracking Number: R44CA199838
Amount: $940,905.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 102
Solicitation Number: PA18-574
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-24
Award End Date (Contract End Date): 2021-08-31
Small Business Information
121 CENTRAL PARK PL, Sanford, FL, 32771-6633
DUNS: 617041967
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (407) 330-3300
Business Contact
Phone: (407) 330-3300
Research Institution
Project Summary Abstract ObjectiveThis project aims to elevate electron beam therapyEBTtechnologywhich provides effective radiation treatment for superficial cancersdepthandltcmto that of other external beam radiotherapiesXRTe gx rays and protonsby bringing electron intensity modulation into the clinicChallengeApproximatelyof radiotherapy patientsin USA annuallyreceive EBT for a portion of their treatmentand as many asof theseannuallymight benefit from bolus electron conformal therapyBECTwhich conforms the distaldose surface to the cancerous planning target volumePTVprotecting adjacent healthy tissueCurrentlyradiation oncologists are limited in using BECT because PTV dose spread can be as great asdue to irregular bolus surfaceThis can be reduced toby spatially modulating incident electron beam intensityHeretoforeelectron intensity modulation delivery technology has been unavailableInnovationUsing our research collaborator s recently invented electron intensity modulator designPhase I demonstrated proof of principle for a PRIMEPassive Radiotherapy Intensity Modulator for Electronsa low cost technology for whichdecimal developed a fabrication methodPRIME consists of a matrix of smalldiametercylindrical tungsten island blocks imbedded in a low density foam in the beam definingcollimating apertureVarying diameters of island blocks placed on a hexagonal grid achieves desired intensity modulationHoweverbecause current treatment planning systemsTPScannot manage PRIMEsan electron TPS needs to be developed as wellResearch DesignPhase II specific aims includerefining the pencil beam redefinition algorithm used for dose calculation under island blockscreating and evaluating an electron specific TPSCOMET PlanComputer Optimized andampModulated Electron Therapy Planningwhich plans intensity modulated bolus electron conformal therapyIM BECTand conventional EBTmanaging treatment aids such as skin collimators and eye shieldsdeveloping factory and clinical PRIME quality assurance methodsperforming a multi institutional treatment planning study to determine the degree to which IM BECT improves BECT dose plansandvalidating IM BECT planning and delivery by comparing doses measured in anthropomorphic phantoms with plannedcalculateddosesHealth BenefitPRIME devices and COMET Plan software will allow a new techniqueIM BECTwhich provides uniform dose conforming to the PTVresulting inequally high chance of cancer controlequally or better low chance of acute normal tissue complicationsanddecreased chance of secondary cancersFor some patientsthis will provide a better dose distribution than other XRT modalitiessuch as volumetric arc therapy or helical tomotherapyimproving their cancer treatmentCommercializationAs the world s leading company producing patient specific radiotherapy devices we are well equipped for bringing PRIME intensity modulators and COMET Plan software to radiotherapy clinicssupporting the excitingnew IM BECT Project Narrative Electron beam therapyEBTan effective modality for radiotherapy of superficialdepthcmcancerspotential US patients yearhas the ability to protect distal healthy tissue from acute and longterm adverse effects of radiationhoweverradiation oncologists are often limited in use of its most powerful delivery techniquebolus electron conformal therapyBECTbecause of excessive dose heterogeneityas great asin the targeted cancer volume due to the irregular proximal surface of the bolusThis SBIR Phase II application proposes to complete research and development of an intensity modulation technologydelivery device and planning softwarethat can be integrated with existing bolus ECT technologypreviously shown to provide a more uniformand equally conformal dose distribution to the targeted cancer volumeHeretoforeno such product has been availablethereforeif developedthis willoffer a new modalityintensity modulated BECTIM BECTtechniqueopen the pathway for further electron intensity modulated radiotherapy researchandimprove all EBT via a newelectron specific treatment planning system that properly manages treatment aidsall three greatly improving current electron radiotherapy technology and potentially providing an improved alternative to other radiation modalities by having decreased chance of secondary cancersequally high chance of cancer controland equally low chance of acute normal tissue complications

* Information listed above is at the time of submission. *

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