Implantable Recording and Integrated Stimulation (IRIS) device for cortical experiments

Abstract We propose to build a hermetically sealed implantable stimulation and recording system to enable closed loop experiments while mitigating the need for percutaneous leadsThe IRISImplantable Recording with Integrated Stimulationis a fully implantable system capable of both stimulating and recording on large numbers of channelschannelsOur implantable technology will provide primate researchers with the ability to perform long duration experiments without risking animal or investigator safetyThese experiments will pave the way towards developing novel translational solutions involving both recording and stimulationCurrent electrophysiological recording and stimulation systems require percutaneous pedestals that present a constant danger of infectiona source of distraction and irritation to the animaland require extensive attention from investigators to clean and maintainInfection is the leading cause of implant failureand annually results in enormous costs in terms of both investigator s time and monetary resourcesRipple proposes to develop the Grapevine IRIS to address this problemRipple has developed component technologies as part of other ongoing development projectsincludingtelemetry protocols for robust inductive powering and high bandwidth transmission of neural signals via IRadvanced amplifier chips capable of low noiselow power performance for detecting neural signalsa stimulation chip optimized for implantable neural interface applicationsand a system architecture for portable programmable neural interface experimentsIn this projectwe will combine these components into a small implantable hermetic package to enable transformative experiments to increase the understanding of dynamic signaling in the nervous system Narrative Understanding the dynamics of neural activity requires new tools to record and manipulate neural signals in realtime in cortical electrophysiology experimentsWe proposed to develop the Grapevine IRISImplantable Recording with Integrated Stimulationsystem to provide a research platform to enable longersaferand better chronic animal studies