Platelet-based Nanoparticle Therapy for Prostate Cancer

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$999,642.00
Award Year:
2010
Program:
SBIR
Phase:
Phase II
Contract:
N44CO201000119
Agency Tracking Number:
N43CO0800063
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
ANDROBIOSYS, INC.
Elm and Carlton Streets, BUFFALO, NY, 14263-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
193493157
Principal Investigator:
MICHAEL ZWICK
Business Contact:
(716) 860-7920
mzwick@androbiosys.com
Research Institution:
n/a
Abstract

The goal of this Phase II proposal is to develop directed energy transfer methods for imaging, tissue ablation and release of therapeutic modalities targeted to the vasculature of prostate cancer. The platform technology is a freeze-dried human platelet (Stasix particles) that contains super paramagnetic iron oxide (SPIO) nanoparticles. The Phase I program showed that SPIO-Stasix particles selectively localize to damaged vasculature in human prostate xenografts on immunocompromised mouse hosts. We propose to further validate the use of human platelet products loaded with iron oxides as delivery vehicles for imaging and therapeutic modalities; to use phage display technology to enhance the targeting of human platelet nanoparticles or synthetic microdevices to prostate cancer microvasculature; to demonstrate that nanodevices targeted to prostate microvasculature can initiate targeted heat-induced damage of the prostate; and to validate and test in clinical trials the therapeutic window induced by androgen deprivation therapy in prostate cancer patients. This proposal represents a full characterization of the targeting, imaging and delivery of heat therapy and contrast agents to prostate microvasculature as a tool for the treatment and diagnosis of prostate cancer.

* information listed above is at the time of submission.

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