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SBIR Phase II: Internal Control Design for a Portable Cholera Pathogen Detector

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1951089
Agency Tracking Number: 1951089
Amount: $942,269.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: BT
Solicitation Number: N/A
Solicitation Year: 2017
Award Year: 2020
Award Start Date (Proposal Award Date): 2020-04-15
Award End Date (Contract End Date): 2022-03-31
Small Business Information
2042 Malibu Drive
West Lafayette, IN 47906
United States
DUNS: 080918577
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Katherine Clayton
 (415) 309-9524
Business Contact
 Katherine Clayton
Phone: (415) 309-9524
Research Institution

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is an inexpensive handheld smartphone device for rapid detection of pathogens, such as cholera, in environmental water sources. Current water-based pathogen detection methods involve a 3-5 day laboratory procedure. Our alternative is a portable smartphone-enabled platform working offline to detect the pathogen in under 30 minutes . When the smartphone has connectivity, geo-mapped and time-stamped detection results are sent to relevant stakeholders. This novel and proactive approach for detection can enable organizations to remediate water sources prior to community infection. This Small Business Innovation Research (SBIR) Phase II project addresses the need to develop a rapid and portable field-ready DNA amplification device for pathogen detection. The Phase II project integrates a polyethylene glycol linker as an internal amplification control for device verification and validation. This project proposes a new assay design integrating a polyethylene glycol linker to eliminate extra user steps, while maintaining assay sensitivity and specificity. The project's technical objectives include systems engineering of an internal amplification control into the hardware functionality of the device. This project will advance the development of a fully integrated sample-to-answer device for detection of waterborne pathogens. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

* Information listed above is at the time of submission. *

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