GAMMA ASSOCIATES PROPOSES TO PRODUCE FOR COMMERCIAL PURPOSESHUMAN MONOCLONAL ANTIBODIES AGAINST RH ANTIGENS ON HUMAN BLOOD CELLS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4980
Agency Tracking Number:
4980
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
61 West 62nd Street, New York, NY, 10023
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KITTIE A MURRAY
PRINCIPAL INVESTIGATOR
(212) 582-2585
Business Contact:
() -
Research Institute:
n/a
Abstract
GAMMA ASSOCIATES PROPOSES TO PRODUCE FOR COMMERCIAL PURPOSESHUMAN MONOCLONAL ANTIBODIES AGAINST RH ANTIGENS ON HUMAN BLOOD CELLS. THE PROJECT HAS BECOME FEASIBLE THROUGH NEWLY DEVELOPED METHODOLOGY ACCESSIBLE TO THE COMPANY. PRODUCTIONSTRATEGY WILL ENTAIL THE TRANSFORMATION BY EPSTEIN-BARR VIRUS OF IMMUNE B CELLS OBTAINED FROM DONORS WHO HAVE HIGH ANTI-RH TITERS AS A RESULT OF RH-INCOMPATIBLE PREGNANCY. LYMPHOBLASTOID CELL LINES THAT PRODUCE RH-SPECIFIC ANTI- BODIES WILL BE STABILIZED BY REPEATED CLONING. CLONED CELLSWILL BE FUSED TO THE HETEROMYELOMA CELL LINE DE33 OR EQUIVALENT MYELOMA CELLS TO PROVIDE HIGH-SECRETING HYBRID- OMAS. THE SPECIFICITY OF ANTI-RH ANTIBODY WILL BE EVALUATEDBY TESTING ON A PANEL OF KNOWN HUMAN RED BLOOD CELLS AND BY SEGREGATION ANALYSIS. THE PURPOSE OF THIS RESEARCH IS TO COLLECT A LARGE SET OF STANDARDIZED, REPRODUCIBLE MONOCLONALANTIBODIES FOR DIAGNOSTIC TYPING OF THE HUMAN RH ANTIGEN SYSTEM. THE COMPANY ANTICIPATES THAT RELEVANT ANTIBODIES WILL EVENTUALLY BE USED FOR PROPHYLACTIC DESENSITIZATION OF WOMEN WHO BEAR RH-INCOMPATIBLE FETUSES. HYBRIDOMA-DERIVED RH ANTIBODIES WILL CONSTITUTE AN INVALUABLE RESOURCE TO REPLACE THE DWINDLING SUPPLY OF NATURALLY OCCURRING RH- IMMUNE GAMMA GLOBULIN.

* information listed above is at the time of submission.

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