A NEW ENZYMATIC TEST FOR THEOPHYLLINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7864
Amount: $458,101.00
Phase: Phase II
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Gds Technology Inc.
25235 Leer Dr, Elkhart, IN, 46514
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THEOPHYLLINE IS A DRUG CURRENTLY USED BY MOST ASTHMATIC/ALLERGIC ADULTS AND CHILDREN, CONSTITUTING OVER SIX MILLION PATIENTS. THERAPY REQUIRES FREQUENT MONITORING OF THEOPHYLLINE LEVELS IN BLOOD AS IT CAUSES TOXICITY AT CONCENTRATIONS HIGHER THAN 20MG/L AND IS INEFFECTIVE AT LOWER THAN 10 MG/L. CURRENT TESTING IS DONE IN HOSPITAL/COMMERCIAL LABORATORIES AT A COST OF $27.00 PER TEST TO MEDICARE/MEDICAID. THERE IS GREAT NEED FOR A COST EFFECTIVE, EASY TO PERFORM TEST FOR THEOPHYLLINE SO THAT PHYSICIANS, IN THEIR OFFICES, OR PATIENTS CAN QUICKLY MONITOR THIS DRUG BY USING A DROP OF WHOLE BLOOD FROM A FINGER TIP. CURRENT TESTS FOR THEOPHYLLINE USE ANTIGEN-ANTIBODY TECHNOLOGY AND ARE CUMBERSOME AND EXPENSIVE. ALTERNATIVELY,GDS TECHNOLOGY'S DISCOVERY OF A NEW ENZYME, NAMELY THEOPHYLLINE OXIDASE, WHICH SELECTIVELY OXIDIZES THEOPHYLLINE COULD ENABLE THE DEVELOPMENT OF A SIMPLE, CONVENIENT, AND SPECIFIC ENZYMATIC TEST. THIS PROPOSAL (PHASE I) FOCUSES ON INITIAL FEASIBILITY STUDIES AND WILL INCLUDE STUDYING THE PROPERTIES OF THIS ENZYME TO ESTABLISH ITS SUITABILITY FOR A COMMERCIAL TEST. THE GOAL OF PHASE II WILL BE THE DEVELOPMENT OF A CONVENIENT ENZYMATIC DRY CHEMISTRY TEST FOR THEOPHYLLINE WHICH WILL COST $1.00-2.00 AND THUS WILL GREATLY REDUCE HEALTH CARE COST.

* information listed above is at the time of submission.

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