MONOCLONAL ANTIBODIES TO HTLV-III/LAV

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4795
Agency Tracking Number:
4795
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Gene Labs Inc (Currently NEUGENESIS CORPORATION)
871 Industrial Road, Building J, San Carlos, CA, 94070
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KOU HWANG
PRINCIPAL INVESTIGATOR
(415) 594-1600
Business Contact:
() -
Research Institution:
n/a
Abstract
MOUSE AND RAT MONOCLONAL ANTIBODIES WILL BE PRODUCED AGAINSTHTLV-III, THE HUMAN RETROVIRUS ASSOCIATED WITH AIDS AND A SPECTRUM OF RELATED SYNDROMES. GENE LABS WILL EMPLOY INTACTHTLV-III VIRIONS COUPLED TO KLH AS AN IMMUNOGEN AND USE A SENSITIVE ELISA ASSAY, BASED ON PURIFIED HTLV-III AS THE ANTIGEN IN OUR PRIMARY SCREENING PROCEDURE. IMMUNOPRECIPI- TATION, WESTERN BLOTTING, AND CELLULAR IMMUNOFLUORESCENCE WILL BE USED TO CHARACTERIZE STABLE, IMMUNOGLOBULIN- SECRETING, ELISA-REACTIVE SUBCLONES. ANTIBODY BINDING CONSTANTS WILL BE ASSESSED BY STANDARD PROCEDURES. FINE MAPPING OF ANTIBODY SPECIFICITY AS IT CORRELATES WITH BIOLOGICAL EFFECTS WILL BE EXAMINED IN THE CONTEXT OF SEPARATE PHASE II FUNDING. PRELIMINARY STUDIES HAVE DEMONSTRATED THE FEASIBILITY OF THE PROPOSAL APPROACH, RESULTING IN THE GENERATION OF BOTH MOUSE AND RAT MONOCLONALANTIBODIES TO HTLV-III DETERMINED ANTIGENS. THE SUCCESSFUL COMPLETION OF THIS PROJECT WILL INVOLVE THE ESTABLISHMENT OFA COMPLETE PANEL OF RAT AND MOUSE MONOCLONAL ANTIBODIES WITHHIGH AVIDITY AGAINST EPITOPES THAT MAY BE WEAKLY IMMUNOGENICOR SILENT IN THE NORMAL HOST.

* information listed above is at the time of submission.

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