IN THIS PROJECT, GENE LABS, INC.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4792
Agency Tracking Number:
4792
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
871 Industrial Road, Building J, San Carlos, CA, 94070
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KOU HWANG
PRINCIPAL INVESTIGATOR
(415) 594-1600
Business Contact:
() -
Research Institute:
n/a
Abstract
IN THIS PROJECT, GENE LABS, INC. WILL PRODUCE AND CHARACTERIZE HUMAN MONOCLONAL ANTIBODIES TO HTLV-III, THE HUMAN RETROVIRUS ASSOCIATED WITH AIDS AND A SPECTRUM OF RELATED SYNDROMES. GENE LABS HAS SUCCESSFULLY USED THE SBC-H20 HETEROMYELOMA CELL LINE AS THE FUSION PARTNER FOR THE GENERATION OF SEVERAL STABLE, IMMUNOGLOBULIN-SECRETING HUMAN B CELL HYBRIDOMAS, INCLUDING ONE DIRECTED AGAINST AN HTLV-III SPECIFIC ANTIGEN. THE VIRAL ANTIGEN SPECIFICITY OFSTABLE ELISA REACTIVE SUBCLONES WILL BE CONFIRMED BY TECHNIQUES INCLUDING IMMUNOPRECIPITATION, WESTERN BLOTTING, AND IMMUNOFLUORESCENCE. THE BINDING CONSTANTS OF THE ANTIBODIES PRODUCED WILL ALSO BE ASSESSED. FINALLY, AS AN OUTGROWTH OF WORK ACCOMPLISHED IN THE COURSE OF THIS PHASE IPROJECT, RESEARCHERS WILL PERFORM FINE SPECIFICITY MAPPING OF THESE ANTIBODIES, CHARACTERIZE THEIR BIOLOGICAL EFFECTS IN PHASE II WORK. THE SUCCESSFUL PRODUCTION OF A SERIES OF HUMAN MONOCLONAL ANTIBODIES DIRECTED AGAINST THE VARIOUS HTLV-III PROTEINS WILL ALLOW AN IN VITRO ASSESSMENT OF THEIRBIOLOGICAL EFFECTS IN A SEARCH FOR THERAPEUTIC EFFICACY.

* information listed above is at the time of submission.

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