THEIR POTENTIAL APPLICATIONS TO A SUBUNIT VACCINE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4793
Agency Tracking Number:
4793
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
871 Industrial Road, Building J, San Carlos, CA, 94070
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GREGORY R REYES
PRINCIPAL INVESTIGATOR
(415) 594-1600
Business Contact:
() -
Research Institute:
n/a
Abstract
HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE I (HTLV-I) IS THE CAUSATIVE AGENT OF AN AGGRESSIVE FORM OF T-CELL LEUKEMIA ENDEMIC TO CERTAIN GEOGRAPHIC AREAS BUT ALSO CURRENTLY INCREASING IN FREQUENCY IN THE SAME POPULATION AT RISK FOR DEVELOPING AIDS. SERO-EPIDEMIOLOGIC DATA SUGGEST THE PRESENCE OF A TYPE-COMMON NEUTRALIZATION DETERMINANT. THIS PROPOSAL SEEKS TO IDENTIFY AND PRODUCE, BY USE OF A RECOMBINANT DNA EXPRESSION SYSTEM, HTLV-I ENCODED EPITOPES TO ASSESS THEIR EFFECT ON IN VITRO MEASURES OF INFECTIVITY AND VIRUS NEUTRALIZATION. IMMUNOREACTIVE EPITOPES CHARACTERIZED IN THIS MANNER HAVE POTENTIAL APPLICATION TO EVENTUAL PRODUCTION OF AN HTLV-I SUBUNIT VACCINE.

* information listed above is at the time of submission.

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