THEIR POTENTIAL APPLICATIONS TO A SUBUNIT VACCINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4793
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Gene Labs Inc
871 Industrial Road, Building J, San Carlos, CA, 94070
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GREGORY R REYES
 PRINCIPAL INVESTIGATOR
 (415) 594-1600
Business Contact
Phone: () -
Research Institution
N/A
Abstract
HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE I (HTLV-I) IS THE CAUSATIVE AGENT OF AN AGGRESSIVE FORM OF T-CELL LEUKEMIA ENDEMIC TO CERTAIN GEOGRAPHIC AREAS BUT ALSO CURRENTLY INCREASING IN FREQUENCY IN THE SAME POPULATION AT RISK FOR DEVELOPING AIDS. SERO-EPIDEMIOLOGIC DATA SUGGEST THE PRESENCE OF A TYPE-COMMON NEUTRALIZATION DETERMINANT. THIS PROPOSAL SEEKS TO IDENTIFY AND PRODUCE, BY USE OF A RECOMBINANT DNA EXPRESSION SYSTEM, HTLV-I ENCODED EPITOPES TO ASSESS THEIR EFFECT ON IN VITRO MEASURES OF INFECTIVITY AND VIRUS NEUTRALIZATION. IMMUNOREACTIVE EPITOPES CHARACTERIZED IN THIS MANNER HAVE POTENTIAL APPLICATION TO EVENTUAL PRODUCTION OF AN HTLV-I SUBUNIT VACCINE.

* information listed above is at the time of submission.

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