HTLV-III/LAV FOR POTENTIAL USE AS A RECOMBINANT SUBUNIT VACCINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4791
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Gene Labs Inc
871 Industrial Road, Building J, San Carlos, CA, 94070
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GREGORY R REYES
 PRINCIPAL INVESTIGATOR
 (415) 594-1600
Business Contact
Phone: () -
Research Institution
N/A
Abstract
HTLV-III/LAV IS A RECENTLY DESCRIBED HUMAN RETROVIRUS LINKEDBOTH MOLECULAR- AND SEROEPIDEMIOLOGICALLY TO THE CURRENT EPIDEMIC OF AIDS. IT SHOULD BE POSSIBLE NOT ONLY TO INTERFERE WITH VIRAL PROPOGATION IN A CHEMOTHERAPEUTIC MANNER BUT ALSO TO EFFECT IMMUNOPROPHYLAXIS IN THE AT-RISK POPULATION, AS THE SYNDROME HAS AN INFECTIOUS ETIOLOGY. THEAIM OF THIS PROJECT IS TO IDENTIFY VIRALLY ENCODED ANTIGENICDETERMINANTS THAT ARE PRODUCED IN A RECOMBINANT DNA EXPRESSION VECTOR BY IMMUNOSCREENING PROTOCOLS. WELL- CHARACTERIZED RECOMBINANT HTLV-III ANTIGENS MAY SERVE AS SEROTYPIC MARKERS OF DISEASE AND WILL BE ASSAYED FOR THEIR EFFECT IN BLOCKING IN VITRO MEASURES OF NEUTRALIZATION. A RECOMBINANT EPITOPE EFFECTIVE IN THE LATTER ASSAY WOULD BE APRIME CANDIDATE FOR A RECOMBINANT SUBUNIT VACCINE.

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government