INHIBITORS OF INTERLEUKIN

Award Information

Agency: Department of Health and Human Services

Branch: N/A

Contract: N/A

Agency Tracking Number: 11061

Amount: $500,000.00

Phase: Phase II

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1991

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

GENELABS TECHNOLOGIES, INC.

505 Penobscot Dr

Redwood City, CA 94063

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Phone: () -

Business Contact

Phone: () -

Research Institution

N/A

Abstract

THIS RESEARCH WILL IDENTIFY AND CLONE ENDOGENOUS INHIBITORY MOLECULES OF INTERLEUKIN-1 (IL-1). HUMAN IMMUNODEFICIENCY VIRUS (HIV)-INFECTED MACROPHAGES AND MACROPHAGE CELL LINES RELEASE TWO INHIBITORS OF IL-1, AN 8-KD MOLECULE AND A 95-KD MOLECULE. POLY (A)(+) MRNA WILL BE PREPARED FROM THESE SOURCES AND CDNA LIBRARIES PREPARED IN LAMBDA GT11 EXPRESSION VECTOR. CLONES WILL BE SCREENED WITH A RABBIT ANTISERUM THAT NEUTRALIZES THE ACTIVITY OF THE 8-KD INHIBITOR. POSITIVE CLONES WILL BE SUBCLONED INTO OKAYAMA-BERG EXPRESSION VECTOR, AND THE ACTIVITY OF TRANSFECTED COS 7 CELL SUPERNATANTS TESTED. IL-1 INHIBITORS HAVE THERAPEUTIC POTENTIAL FOR IMMUNOINFLAMMATORY DISEASES. STUDY OF THESE MOLECULES MAY PROVIDE A BETTER UNDERSTANDING OF THE PATHOGENESIS OF AIDS.

* Information listed above is at the time of submission. *

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INHIBITORS OF INTERLEUKIN