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Recombinant HEV-Like Particles as a Potential Vaccine

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI35400-1,
Agency Tracking Number: 24765
Amount: $77,900.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1994
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
505 Penobscot Drive
Redwood City, CA 94063
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Patrice Yarbough
 (210) 690-6050
Business Contact
Phone: () -
Research Institution

Hepatitis E virus (HEV) infections represent a major health problem in developing countries whereepidemics primarily affect young to middle-age adults. Although HEV does not lead to chronic hepatitisor cirrhosis, the infection is severe enough to warrant prevention. We will demonstrate that the capsidprotein of HEV can self-assemble into particles that are morphologically similar to native HEV virions.We propose that self-assembled virus-like particles expressed from the HEV caps id protein wouldpreserve conformational neutralizing epitopes and, therefore, be an ideal vaccine candidate for long-termprotective immunity. The putative capsid protein will be expressed in several expression systems alongwith other putative structural proteins of the virus. Protein products will be inspected for theself-assembling of virus-like particles. Purified virus-like particles will then be tested for antigenicity tovalidate the conservation of immunologically important epitopes.

* Information listed above is at the time of submission. *

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