SBIR PHASE I: A Technology that Improves Gene Targeting

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0740278
Agency Tracking Number: 0740278
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solicitation Year: N/A
Solicitation Topic Code: BT
Solicitation Number: NSF 07-551
Small Business Information
9103 LAWN AVENUE, St Louis, MO, 63144
DUNS: 145404971
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 UTHAYASHANKER EZEKIEL
 PhD
 (314) 583-5441
 uezekiel@geneprotech.com
Business Contact
 UTHAYASHANKER EZEKIEL
Title: PhD
Phone: (314) 583-5441
Email: uezekiel@geneprotech.com
Research Institution
N/A
Abstract
This Small Business Innovation Research (SBIR) Phase I research project aims to improve the frequency of homologous recombination by increasing the number of targeting vector molecules that reach the nucleus. The technology is based on constructing targeting vectors that have proteins involved in nuclear translocation attached. Recombination events that can target an exogenous DNA constructs to a particular gene are relatively rare due to a variety of reasons, one of the most important of which is the low frequency of transport across the nuclear membrane. Thus, an approach based on the use of members of a cell's own nuclear translocation machinery is likely to improve the odds of successful recombination events. Important therapeutic modalities such as gene therapy are dependent upon the efficient targeting of specific chromosomal loci. Development of methodologies that enhance nuclear targeting would improve the odds of successful recombination events and as such would not only be important for gene therapy, but also for the creation of novel animal models, which is also dependant on homologous recombination.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government