SBIR PHASE I: A Technology that Improves Gene Targeting

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$100,000.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
0740278
Award Id:
88252
Agency Tracking Number:
0740278
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9103 LAWN AVENUE, St Louis, MO, 63144
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
145404971
Principal Investigator:
UTHAYASHANKER EZEKIEL
PhD
(314) 583-5441
uezekiel@geneprotech.com
Business Contact:
UTHAYASHANKER EZEKIEL
PhD
(314) 583-5441
uezekiel@geneprotech.com
Research Institute:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase I research project aims to improve the frequency of homologous recombination by increasing the number of targeting vector molecules that reach the nucleus. The technology is based on constructing targeting vectors that have proteins involved in nuclear translocation attached. Recombination events that can target an exogenous DNA constructs to a particular gene are relatively rare due to a variety of reasons, one of the most important of which is the low frequency of transport across the nuclear membrane. Thus, an approach based on the use of members of a cell's own nuclear translocation machinery is likely to improve the odds of successful recombination events. Important therapeutic modalities such as gene therapy are dependent upon the efficient targeting of specific chromosomal loci. Development of methodologies that enhance nuclear targeting would improve the odds of successful recombination events and as such would not only be important for gene therapy, but also for the creation of novel animal models, which is also dependant on homologous recombination.

* information listed above is at the time of submission.

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