SBIR Phase I: Develop a Diagnostic Test for Direct Detection of Mycobacterium Avium Subsp. Paratuberculosis

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$78,725.00
Award Year:
2006
Program:
SBIR
Phase:
Phase I
Contract:
0611282
Award Id:
79492
Agency Tracking Number:
0611282
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4711 Innovation Drive, Lincoln, NE, 68521
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Susanne Hinkley
Dr
(402) 435-0665
shinkley@geneseek.com
Business Contact:
Susanne Hinkley
Dr
(402) 435-0665
shinkley@geneseek.com
Research Institute:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase I research project will develop a novel diagnostic test to detect Mycobacterium avium subsp. paratuberculosis (MAP). MAP is the causative agent of Johnes disease in cattle and, possibly, of human Crohns disease. A novel approach of early and direct MAP detection is proposed, targeting primarily thevsample matrix blood employing a novel detection system using the near-infrared spectrum to achieve superior sensitivity of testing. This would facilitate testing of cattle and also milk intended for human consumption, the potential transmission vehicle in Crohns disease. The hypothesis is that during the early pathogenesis of Johnes disease of cattle, there is a bacteremia that will allow detection of the causative agent in the blood. If proven true, it is expected that this approach will lead to a new test that may be used widely in the context of state or national animal health or human food safety programs.

* information listed above is at the time of submission.

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