SBIR Phase I: Develop a Diagnostic Test for Direct Detection of Mycobacterium Avium Subsp. Paratuberculosis

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0611282
Agency Tracking Number: 0611282
Amount: $78,725.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2005
Solicitation Topic Code: BT
Solicitation Number: NSF 05-605
Small Business Information
4711 Innovation Drive, Lincoln, NE, 68521
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Susanne Hinkley
 (402) 435-0665
Business Contact
 Susanne Hinkley
Title: Dr
Phone: (402) 435-0665
Research Institution
This Small Business Innovation Research (SBIR) Phase I research project will develop a novel diagnostic test to detect Mycobacterium avium subsp. paratuberculosis (MAP). MAP is the causative agent of Johnes disease in cattle and, possibly, of human Crohns disease. A novel approach of early and direct MAP detection is proposed, targeting primarily thevsample matrix blood employing a novel detection system using the near-infrared spectrum to achieve superior sensitivity of testing. This would facilitate testing of cattle and also milk intended for human consumption, the potential transmission vehicle in Crohns disease. The hypothesis is that during the early pathogenesis of Johnes disease of cattle, there is a bacteremia that will allow detection of the causative agent in the blood. If proven true, it is expected that this approach will lead to a new test that may be used widely in the context of state or national animal health or human food safety programs.

* Information listed above is at the time of submission. *

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