HAMSTER OVARY CELLS IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO EXAMINE FURTHER THE HYPOTHESIS THAT THE PRESENCE OF SMALL MOUSE LYMPHOMA COLONIES IN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3153
Agency Tracking Number:
3153
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2224 Old Middlefield Way, Suit, E C, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ANN D. MITCHELL
PRINCIPAL INVESTIGATOR
(415) 968-3635
Business Contact:
() -
Research Institution:
n/a
Abstract
HAMSTER OVARY CELLS IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO EXAMINE FURTHER THE HYPOTHESIS THAT THE PRESENCE OF SMALL MOUSE LYMPHOMA COLONIES IN A BIMODAL DISTRIBUTION OF COLONY SIZES IS CORRELATED WITH THE PRESENCE OF CHROMOSOMALLY ABERRANT CELLS AND TO DETERMINE WHY CHEMICALS THAT ARE MUTAGENIC IN THE MLA HAVE FAILED TO PRODUCE CHROMOSOMAL ABERRATIONS IN CHINESE HAMSTER OVARY (CHO) CELLS. IN ORDER TO DEMONSTRATE THE FEASIBILITY OF THIS RESEARCH AND THE LABORATORY'S CAPABILITIES, PHASE I EFFORTS WILL BE DIRECTED PRIMARILY TOWARD USING A MORE SENSITIVE CYTOGENETIC ASSAY PROTOCOL TO EXAMINE CHROMOSOMAL ABERRATION FREQUENCIES IN MOUSE LYMPHOMA AND CHO CELLS EXPOSED TO 6 CHEMICALS THAT ARE MUTAGENIC IN THE MLA BUT NEGATIVE IN THE CHO CHROMOSOMAL ABERRATION ASSAY. THESE RESULTS WILL BE COMPARED WITH THE DISTRIBUTIONS OF COLONY SIZES FROM MLAS OF THE SAME 6 CHEMICALS.

* information listed above is at the time of submission.

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