REPRODUCIBILITY OF MOUSE LYMPHOMA MUTAGENESIS ASSAY RESULTS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3154
Agency Tracking Number:
3154
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2224 Old Middlefield Way, Suit, E C, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ANN D. MITCHELL
PRINCIPAL INVESTIGATOR
(415) 968-3635
Business Contact:
() -
Research Institute:
n/a
Abstract
IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO DETERMINE WHETHER VARIABILITY IN MUTATION FREQUENCY RATIOS BETWEEN EXPERIMENTS IS COMPOUND SPECIFIC OR THE RESULT OF VARIABILITY IN TESTING CONDITIONS AND TO DETERMINE WHETHER COLONY SIZE DISTRIBUTIONS ARE A GOOD INDEX OF VARIABILITY OR SIMILARITY OF TESTING CONDITIONS. IN ORDER TO DEMONSTRATE THE FEASIBILITY OF THIS RESEARCH AND THE LABORATORY'S CAPABILITIES, PHASE I EFFORTS WILL BE DIRECTED PRIMARILY TOWARD DETERMINING COLONY SIZE DISTRIBUTIONS IN MOUSE LYMPHOMA TESTS OF 6 CHEMICALS MUTAGENIC IN THE MLA BUT NEGATIVE IN THE CHINESE HAMSTER OVARY (CHO) CHROMOSOMAL ABERRATION ASSAY. THESE RESULTS WILL BE COMPARED WITH THE RESULTS FROM ASSAYS FOR CHROMOSOMAL ABERRATIONS IN ML AND CHO CELLS TO DETERMINE WHETHER RATIOS OF TREATED TO SOLVENT CONTROL MUTATION FREQUENCIES VARY IN THE SAME MANNER AS RATIOS OF THE NUMBER OF CHROMOSOMAL ABERRATIONS IN TREATED VERSUS SOLVENT CONTROL SAMPLES.

* information listed above is at the time of submission.

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