Preferential Display (PD) based PROTECT system

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-04-C-6470
Agency Tracking Number: F031-0390
Amount: $749,698.00
Phase: Phase II
Program: SBIR
Awards Year: 2004
Solicitation Year: 2003
Solicitation Topic Code: AF03-063
Solicitation Number: 2003.1
Small Business Information
PO Box 200759, Austin, TX, 78729
DUNS: 807519264
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Robert Chin
 (512) 659-4539
 rchin@austin.rr.com
Business Contact
 Rick Virgne
Phone: (512) 990-1200
Email: rvirgne@swbell.net
Research Institution
N/A
Abstract
During the Phase I, GeneXpress Informatics (GXI) provided proof-of-concept for the Preferential Display (PD) technology. GXI's Preferential Display (PD) technology is a paradigm shift in high throughput gene expression and analysis. The PD technology eliminates redundant sequences found between tissue types or conditions by using a novel combination of biomolecular chemistry methods and fluorescence dye assay techniques. In this Phase II, GXI proposes to optimize the PD technology by expanding the usage to other cell lines which are of interest to the Air Force. GXI intends to perform the optimization of the PD protocols for these cell lines and will also investigate alternative methodologies and transition the technology into a viable commercial enterprise. GXI also intends to pursue the assembly of a high throughput PD gene expression laboratory to provide gene based drug target databases and contract services for pharmaceutial and Air Force needs for target validation and metabonomics gene expression. As a final deliverable, GXI will provide the Air Force with PD assay kits which will include reagents, assay protocols and a internal standard.

* Information listed above is at the time of submission. *

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