High Throughput Genomics Screening for Malaria Antigen Discovery

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$69,993.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W81WXH-05-C-0108
Agency Tracking Number:
A043-189-0667
Solicitation Year:
2004
Solicitation Topic Code:
A04-189
Solicitation Number:
2004.3
Small Business Information
GENVEC, INC.
65 W. Watkins Mill Road, Gaithersburg, MD, 20878
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Joseph Bruder
Director, Vaccines and Vector Progr
(240) 632-5543
jbruder@genvec.com
Business Contact:
C. Richter King
Vice President, Research
(240) 632-5537
rking@genvec.com
Research Institution:
n/a
Abstract
Malaria is a major threat to world health and the personnel of the US armed forces. To date there is no available effective protective vaccine. However, an abundance of data in animal models and in humans has indicated the existence of protective antigens and demonstrated that an effective vaccine against malaria is feasible. Unfortunately, the most effective vaccine, based on radiation attenuated Plasmodium falciparum sporozoites, is not practical for mass use. The overall goal of this proposal is to develop a technology that can identify and prioritize novel protective target antigens for vaccine development. Our hypothesis is that P. yoelii antigens that are recognized by irradiated sporozoite immunized mice can be identified using an in vitro system and that such antigens will elicit strong protective immune responses when delivered in a potent vaccine. Furthermore, the corresponding P. falciparum orthologues will be excellent vaccine candidates. The phase I SBIR focuses on the feasibility of the screen; objective #1 focuses on methods to generate antigen carrying vectors, objective #2 focuses on the assays to identify T-cells specificities from immune animals, and objective #3 focuses on the use of proprietary adenoviral targeting technology to improve the sensitivity and through-put of the screen.

* information listed above is at the time of submission.

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