Development of an Ad14 Vaccine

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,313.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI082771-01
Award Id:
93406
Agency Tracking Number:
AI082771
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
GENVEC, INC., 65 W WATKINS MILL RD, GAITHERSBURG, MD, 20878
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
806729547
Principal Investigator:
JASON GALL
(240) 632-5547
JGALL@GENVEC.COM
Business Contact:
BROUGH DOUGLAS
() -
dbrough@genvec.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Recent reports indicate that a new strain of adenovirus serotype 14 (Ad14) is causing frequent acute respiratory disease (ARD) and deaths in otherwise health people. The overall goal of this SBIR is to generate a vaccin e that can protect against Ad14 infection and disease. Our hypothesis is that an Ad14 vector particle that is made non-replicating by means of a deletion in the E1 region, Ad14nr, will be an effective and safe vaccine. Preliminary data supporting this stra tegy has been obtained. In the phase I portion of this application we will test the feasibility of our strategy by generating an Ad14nr prototype vaccine, testing its yield and quality of production, evaluating immunogenicity and initial testing for safety . In the phase II portion of this SBIR we will conduct IND enabling production and quality testing under Good Manufacturing Practice and complete required safety and biodistribution studies. PUBLIC HEALTH RELEVANCE: Recent reports indicate that a new strai n of adenovirus serotype 14 (Ad14) is causing frequent acute respiratory disease (ARD) and deaths in otherwise healthy people. The overall goal of this SBIR is to generate a vaccine that can protect against Ad14 infection and disease.

* information listed above is at the time of submission.

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