THE ULTIMATE GOAL OF THE PROGRAM IS TO DEVELOP A PRACTICAL MICROELECTRODE WHICH IS CAPABLE OF RELIABLY MEASURING LOCAL CARBON DIOXIDE AND OXYGEN TENSIONS CONCURRENTLY, IN TISSUE AND BODY FLUIDS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,949.00
Award Year:
1983
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
478
Agency Tracking Number:
478
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
14 Spring Street, Waltham, MA, 02154
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DAVID K. WONG
PRINCIPAL INVESTIGATOR
(617) 899-7270
Business Contact:
() -
Research Institution:
n/a
Abstract
THE ULTIMATE GOAL OF THE PROGRAM IS TO DEVELOP A PRACTICAL MICROELECTRODE WHICH IS CAPABLE OF RELIABLY MEASURING LOCAL CARBON DIOXIDE AND OXYGEN TENSIONS CONCURRENTLY, IN TISSUE AND BODY FLUIDS. CONTINUOUS IN-SITU MONITORING OF PCO(2) AND PO(2) CAN HAVE SIGNIFICANT IMPACT IN INTENSIVE CARE, OPERATING ROOMS, AND RESEARCH LABORATORIES. THE PRINCIPAL APPLICATIONS OF SUCH A DEVICE INCLUDE MANAGEMENT OF VENTILATION, ACID-BASE BALANCE, AND BASIC RESEARCH. THE PCO(2) MEASUREMENT IS BASED ON THE QUANTITATIVE DETERMINATION OF THE AMOUNT OF "REDUCED-CO(2)" ABSORBED ON THE PT-BASED WORKING ELECTRODE. PO(2) IS OBTAINED BY MEASURING THE O(2) REDUCTION LIMITING CURRENT IN A WELL DEFINED POTENTIAL REGION. THE PCO(2) AND PO(2) MEASUREMENTS CAN BE MADE AT A HIGH SAMPLING RATE WITHOUT MUTUAL INTERFERENCE. THE PROPOSED MICROELECTRODE IS A FINE WIRE ELECTRODE (E.G. 25 MICRONS IN DIAMETER) WITH A SHARP TIP. GASES TO BE MEASURED PERMEATE THROUGH THE HYDROPHOBIC MEMBRANE COVERING THE TIP AND EQUILIBRATE WITH ELECTROLYTE BEHIND THIS HYDROPHOBIC LAYER. THE WORK PLANNEDIN PHASE I WILL BE CARRIED OUT IN TWO ITERATIVE STAGES. THEFIRST STAGE INVOLVES THE FABRICATION AND EVALUATION OF MICROELECTRODES IN A NUMBER OF PRELIMINARY CONFIGURATIONS. IN THE SECOND STAGE, A FEW ELECTRODES WILL BE FABRICATED USING THE MOST PROMISING CONSTRUCTION DESIGN TO FURTHER REFINE THEIR OPERATING PARAMETERS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government