DEVELOPMENT OF AN ELECTROCHEMICAL REGENERATIVE ARTIFICIAL KI

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2971
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
14 Spring Street, Waltham, MA, 02254
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jose Giner
 Principal Investigator
 (617) 899-7270
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OBJECTIVE OF THIS EFFORT IS THE DEVELOPMENT OF A COMPACT, EFFICIENT, AND ECONOMICAL PORTABLE ARTIFICIAL KIDNEY BASED ON ELECTROCHEMICAL REGENERATIVE DIALYSIS. IN THIS SYSTEM, AN ELECTROCHEMICAL REACTOR IS USED TO DEGRADE WASTE PRODUCTS, PRINCIPALLY UREA, TO BENIGN GASEOUS REACTION PRODUCTS. THE COMPLETE REGENERATION SYSTEM ALSO INCLUDES A STANDARD DIALYZER, AN ACTIVATED CARBON BED TO ABSORB ORGANICS AND TRACES OF CHLORINATED SPECIES, ION EXCHANGE BEDS TO REMOVE EXCESS ANIONS AND CATIONS, AND ANCILLARY EQUIPMENT (DC POWER SUPPLY FOR THE ELECTROCHEMICAL REACTOR, PUMPS, SENSORS, THE DEVELOPMENT EFFORT INCLUDES SYSTEM MODELING, DESIGN, CONSTRUCTION, AND CHARACTERIZATION OF AN IMPROVED REACTOR. THE SOLUTION KINETICS FOR THE REACTION OF HCLO WITH UREA (AND OTHER METABOLITES) WILL BE DETERMINED. THE DIALYSATE WILL BE ANALYZED QUANTITATIVELY TO IDENTIFY ALL CHLORINATED ORGANICS AND DETERMINE THEIR FINAL DISPOSITION. EXTENSIVE TOXICITY TESTS WILL BE CONDUCTED ON THE REGENERATED DIALYSATE TO MAKE CERTAIN THAT NO NEW TOXIC PRODUCTS ARE RETURNED BY THE SYSTEM. A COMPLETE SYSTEM WILL BE ASSEMBLED AND DEMONSTRATED. THE ADVANTAGES OF THE PROPOSED DEVICE INCLUDE: SMALLER SIZE AND WEIGHT THAN AVAILABLE SYSTEMS, FLEXIBLE CONFIGURATION, CAPABILITY FOR EXTENDED AND REPEATED USE, OVERALL ECONOMY, & THE POTENTIAL FOR DEVELOPING A WEARABLE ARTIFICAL KIDNEY.

* Information listed above is at the time of submission. *

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