Oxygen/Carbon Dioxide Miniature Sensor for Space Bioreactors

Award Information
Agency:
National Aeronautics and Space Administration
Amount:
$599,795.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2001
Phase:
Phase II
Agency Tracking Number:
990153
Solicitation Topic Code:
N/A
Small Business Information
Giner, Inc.
14 Spring Street, Waltham, MA, 02451
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Linda Ph.D.
 Project Manager, Biomed./Mat'l
 () -
 ginerinc@compuserve.com
Business Contact
 Anthony B LaConti, Ph.D.
Title: President
Phone: (781) 899-7270
Email: ginerinc@compuserve.com
Research Institution
N/A
Abstract
Giner, Inc. proposes to develop a miniature electrochemical sensor that detects, in a single sensor, dissolved O2 as well as CO2 for use in space bioreactors. The proposed sensor will be insensitive to membrane fouling and hydrodynamic effects, providing accurate measurements without recalibration. The oxygen detection method will use a novel mode of sensing that is insensitive to fluid flow and membrane fouling. By using a CO2 sensing scheme that involves chemisorbing a ¿reduced-CO2¿ species on a platinum electrode and then stripping by anodically ramping, we can measure CO2 using the same working electrode or a second working electrode within the same sensor. Signal will be linearly related to pCO2, rather than logarithmically related as in conventional (Severinghaus) CO2 detection, leading to greater accuracy. A periodic, steady-state oxygen measurement will indicate the extent of fouling and a correlation will be developed to correct the CO2 measurement. Giner, Inc. is uniquely suited to develop this advanced probe for NASA microgravity bioreactors based on our previous extensive experience with individual O2 and CO2 sensors for clinical applications.

* information listed above is at the time of submission.

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