Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$2,306,701.00
Award Year:
2009
Program:
SBIR
Phase:
Phase II
Contract:
2R44ES016412-03
Agency Tracking Number:
ES016412
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
GINER, INC.
89 RUMFORD AVENUE, NEWTON, MA, 02466
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
066594979
Principal Investigator:
BADAWI DWEIK
(781) 529-0520
BDWEIK@GINERINC.COM
Business Contact:
ANTHONY LACONTI
() -
alaconti@ginerinc.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The toxicity of trace heavy metals found in drinking water, food, and the environment is an area of increasing national and international concern. Heavy metals are significant environmental pollutants because they tend to persist, tend to bioaccumulate and can result in serious adverse health effects when ingested or inhaled. Measurement of human exposure in the population serves in determination of safe regulatory exposure limits and prevention of diseases caused by he avy metals. Trace metals can be measured in human tissue or fluids such as blood or urine in centralized laboratories using complex analytical methods such as high-performance liquid chromatography inductively coupled plasma mass spectroscopy. However, in view of the high labor and analytical costs and long time delays associated with centralized laboratory analyses, there is an immediate need for a portable and inexpensive system for on-site monitoring of human exposure to heavy metals. The overall objecti ve of this project is to develop a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, manganese and lead metals from a single urine sample, in near real time, to assess personal exposure. The proposed se nsor combines a specialized electrochemical measurement technique with a unique microarray electrode material and configuration for unprecedented sensitivity and selectivity, under real-world operating conditions. During Phase I, Giner, Inc. developed sens or design configurations, electrode material compositions, and operating conditions which demonstrated the feasibility of the unique microchip sensor prototype for the detection of arsenic and cadmium species at 0.2 ppb level in water. Testing in urine is ongoing in the Phase I program, with arsenic and cadmium detected in the initial studies at 100 ppb with a response magnitude indicating a lower detection limit will be attained in the last four months of Phase I. The Specific Aims of this intensive Phase II program encompass design, fabrication and validation testing of a prototype field-portable analytical system for detection of a broader range of heavy metals (including arsenic, cadmium, manganese and lead) at concentrations in the relevant ppb and sub- ppb levels in water and in urine. The performance of the monitor will be extensively characterized for sensitivity, selectivity, robustness and ease-of-use in real-world samples and field situations. During the Phase II program, five prototype compact pack aged units will be fabricated for use in ongoing epidemiological studies in three field locations (Bangladesh, Tar Creek, OK and Mexico City) in collaboration with Harvard School of Public Health. Subsequent to Phase II, the five prototypes will be ready f or use in additional field research prior to its introduction as a commercial product for multiple markets in research, environmental and health monitoring. PUBLIC HEALTH RELEVANCE: Human exposure to toxic heavy metals is common in the U.S. and int ernationally with serious adverse health effects. This Phase II SBIR research is for development a portable monitor for measuring toxic metals (arsenic, cadmium, lead and manganese) in the urine as a way to rapidly, inexpensively assess personal exposure. A portable field monitor will facilitate the ease, rapidness and cost-effectiveness of public health monitoring and research studies to understand the relationship between chemical exposure and disease outcomes.

* information listed above is at the time of submission.

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