ENZYMATIC RENATURATION OF RECOMBINANT PROTEINS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19205
Agency Tracking Number:
19205
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
7166 Manchester Road, St Louis, MO, 63143
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Paul Gold
(314) 647-2509
Business Contact:
() -
Research Institution:
n/a
Abstract
BACTERIAL EXPRESSION SYSTEMS DESIGNED TO PRODUCE LARGE AMOUNTS OF PROTEINS FOR MEDICAL, INDUSTRIAL OR RESEARCH USE ARE STAPLES IN THE REPERTOIRE OF RECOMBINANT DNA TECHNOLOGY. ONE REQUIREMENT IS THAT THE PROTEIN BE EASILY PURIFIED AND IN AS ACTIVE A FORM AS POSSIBLE. WE WILL USE A CLONED RECOMBINANT ENZYME AS A MEANS TO MAXIMIZE THE YIELD OF BIOLOGICALLY ACTIVE PROTEINS THAT CAN ABE OBTAINED FROM BACTERIAL EXPRESSION SYSTEMS. EXPERIMENTS WILL BE PERFORMED ON TEST RECOMBINANT PROTEINS IN ORDER TO SEE IF THE YIELD OF BIOLOGICALLY ACTIVE NATIVE MOLECULES CAN BE INCREASED.

* information listed above is at the time of submission.

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