H.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3242
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
H. G. Pars Pharmaceutical Labo
763 Concord Avenue, Cambridge, MA, 02138
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HARRY G. PARS
PRINCIPAL INVESTIGATOR
(617) 354-2800
Business Contact:
() -
Research Institution:
n/a
Abstract
H. G. PARS PHARMACEUTICAL LABORATORIES' LONG-TERM GOAL IS TO DEVELOP AND MARKET AN ORALLY ACTIVE ANTIHYPERTENSIVE DRUG FROM ITS SERIES OF SULFUR AND NITROGEN CANNABINOID ANALOGS. HYPOTENSIVE CANNABINOIDS ARE BELIEVED TO EXERT THEIR EFFECTS BY ALTERING CENTRAL SYMPATHETIC NERVOUS SYSTEM ACTIVITY BUT THE EXACT MECHANISM OF ACTION IS NOT KNOWN AND MAY DIFFER FROM THAT OF ANTIHYPERTENSIVE AGENTS ON THE MARKET. PRELIMINARY CARDIOVASCULAR/BEHAVIORAL DATA INDICATE THAT 4 PARS COMPOUNDS (SP-119, SP-269, 273, AND 276) SHOW A FAVORABLE SEPARATION OF BLOOD PRESSURE-LOWERING ACTIVITY AND ADVERSE SIDE EFFECTS. HYPOTENSIVE ACTIVITY IN CONSCIOUS AND ANESTHETIZED SPONTANEOUS HYPERTENSIVE (SH) AND NORMOTENSIVE RATS WAS OF LONG DURING PHASE I, WE WILL RESYNTHESIZE THE 4 ANALOGS AND PERFORM MORE EXTENSIVE EVALUATIONS OF THEIR ANTIHYPERTENSIVE ACTIVITY IN SH RATS AND BEHAVIORAL EFFECTS IN MICE. THE CANDIDATE WITH THE BEST THERAPEUTIC RATIO, SP-X, WILL UNDERGO FURTHER EVALUATION IN A 20-DAY REPEAT SUCCESSFUL COMPLETION OF THIS PROJECT WILL ALLOW APPLICATION FOR PHASE II FUNDS FOR PREPARING AN ORAL FORMULATION OF SP-X, PERFORMING PRECLINICAL STUDIES, AND CONDUCTING

* information listed above is at the time of submission.

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